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个人简介
Richard Vierstra’ laboratory has directed their research to two main questions; how do cells selectively recycle proteins? And how does light influence the growth and development of plants? The recycling studies first focused on the ubiquitin/proteasome proteolytic system, showing how it is organized, regulated, and chooses appropriate targets using a large cohort of ubiquitin ligases in the model plant Arabidopsis. Particularly information has been the use of mass spectrometry to catalog the plethora of ubiquitylation targets. Their research is now directed at the autophagy system, with discoveries that a number of organelles, protein complexes and a substantial portion of plant proteomes are influenced by this turnover. In particular, his group found a novel autophagic mechanism for clearing proteasomes that involves a sequence of ubiquitylation and aggregation events. Studies on phytochromes have centered on understanding how these photoreceptors convert light into a conformation signal that initiates downstream signaling cascades. Particularly notable were the development of the first atomic resolution structures of the photosensing region in both its ground and photoactivated states, using crystallographic, 2D-NMR and cryo-EM techniques, to reveal the early structural changes underpinning light perception. In addition, the Vierstra lab has characterized SUMO system in plants and how this post-translational modifier promotes stress tolerance.
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E Sethe Burgie,Katherine Basore,Michael J Rau, Brock Summers, Alayna J Mickles, Vadim Grigura, James A J Fitzpatrick,Richard D Vierstra
Nature communicationsno. 1 (2024): 6853-6853
Journal of Biological Chemistryno. 7 (2024): 107369-107369
Han Nim Lee,Jenu Varghese Chacko,Ariadna Gonzalez Solis,Kuo-En Chen,Jessica A. S. Barros,Santiago Signorelli,A. Harvey Millar,Richard David Vierstra, Kevin W. Eliceiri, Marisa S. Otegui, Yoselin Benitez-Alfonso
Plant physiologyno. 2 (2023): 1395-1415
Plant directno. 7 (2023): e506-e506
Nature Plants (2023): 1116-1129
Journal of Biological Chemistryno. 3 (2023): 103943-S505
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作者统计
#Papers: 341
#Citation: 34671
H-Index: 101
G-Index: 180
Sociability: 7
Diversity: 3
Activity: 38
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