基本信息
浏览量:4
职业迁徙
个人简介
Women who carry germline mutations in the BRCA1 tumor suppressor gene are prone to develop basal-like triple-negative breast tumors, an especially lethal subtype of human breast cancer. Richard Baer studies the mechanisms by which BRCA1 suppresses tumor formation and how these mechanisms are disrupted in BRCA1 mutation carriers. In vivo, BRCA1 exists in the form of a heterodimer with another structurally-related tumor suppressor, the BARD1 protein. Most of the cellular functions attributed to BRCA1, including its critical activities in genome stability and tumor suppression, are mediated by the BRCA1/BARD1 heterodimer. The Baer laboratory uses biochemical, cellular, and organismal approaches to characterize the BRCA1/BARD1 complex and its associated factors, such as the DNA repair protein CtIP. These studies seek to define the biological functions of the BRCA1/BARD1 pathway, particularly with respect to maintenance of genome stability, and how the loss of these functions promotes breast and ovarian cancer.
研究兴趣
论文共 62 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Daniela Georgieva, Ning Wang,Angelo Taglialatela, Stepan Jerabek,Colleen R. Reczek,Pei Xin Lim, Julie Sung, Qian Du,Michiko Horiguchi,Maria Jasin,Alberto Ciccia,Richard Baer,
Giuseppe Leuzzi,Alessandro Vasciaveo, Angelo Taglialatela,Xiao Chen, Tessa M. Firestone, Allison R. Hickman,Wendy Mao, Tanay Thakar, Alina Vaitsiankova, Jen-Wei Huang,Raquel Cuella-Martin, Samuel B. Hayward,
CELLno. 4 (2024): 861-881.e32
Proceedings of the National Academy of Sciences of the United States of Americano. 31 (2023)
引用0浏览0WOS引用
0
0
Cellsno. 23 (2023): 2762
Proceedings of the National Academy of Sciences of the United States of Americano. 38 (2021)
Ahmad Rushdi Shakri,Timothy James Zhong,Wanchao Ma,Courtney Coker, Rohaan Hegde,Hanna Scholze, Vanessa Chin,Matthias Szabolcs,Hanina Hibshoosh,Kurenai Tanji,Richard Baer,Anup Kumar Biswas,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn