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Bio
Rick Silverman(May 12, 1946-),The research in my group can be summarized as investigations of the rational design, syntheses, and molecular mechanisms of action of potential medicinal agents. The primary focus is basic research into central nervous system disorders, including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Lewy body dementia, cerebral palsy, epilepsy, and neuropathic pain. Other therapeutic areas include cancer (melanoma and hepatocellular carcinoma). Numerous drugs are known to function as specific inhibitors of particular enzymes. For some enzyme targets, where potent reversible inhibitors are desired, computer modeling based on X-ray crystal structures initiates the research (high-throughput screening also may be used). For enzyme targets where inactivators are desired, mechanism-based inactivators are designed and synthesized and inactivation and metabolism mechanisms investigated. The enzymes are isolated from overexpressed cells containing recombinant enzymes. Collaborations are developed in X-ray crystallography and preclinical studies. We have invented several drugs, one of which (Lyrica) is on the drug market and three others have been or are in clinical trials.
Research Interests
Papers共 576 篇Author StatisticsCo-AuthorSimilar Experts
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Allison N Devitt, Abigail L Vargas,Wei Zhu,Benjamin James Des Soye,Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley,Glaucio M Ferreira,Graham R Moran,Neil L Kelleher,Dali Liu,Richard B Silverman
ACS chemical biologyno. 5 (2024): 1066-1081
BIOCHEMISTRYno. 6 (2024): 788-796
Cancer Researchno. 6_Supplement (2024): 5938-5938
The Journal of organic chemistryno. 12 (2024): 9110-9117
The Journal of Organic Chemistry (2024)
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 17 (2023): 9895-9896
Journal of medicinal chemistryno. 14 (2023): 9934-9953
Medicinal research reviewsno. 6 (2023): 2260-2302
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