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During the last years, my research activity has been focused on the characterization of the molecular targets involved in the induction of apoptosis by anion transporters, like prodigiosin and/or obatoclax, as well as in identifing new molecules of therapeutic interest in the treatment of cancer. Some of these research projects were in collaboration with international colleagues like Prof. Mike Levin. Medical School, University of Harvard (USA); Prof. James Lambert, Dept. of Pathology, University of Colorado Denver and Health Science Center, Aurora, Colorado (USA); Prof. Alnawaz Rehemtulla from the Department of Radiation Oncology, University of Michigan Medical School (USA). On the other hand, in order to identify new molecules of therapeutic interest in the treatment of cancer, few years ago my research group started the collaboration with the Organic Chemistry Group lead by Prof. Roberto Quesada at the University of Burgos and with Prof. Phil Gale form the Chemistry Dept. at the University of Southampton (UK). We have already obtained significant results that offer proof of concept for this idea of using anion transporters as cancer chemotherapeutic agents. Our latest results involve the study of marine alkaloid tambjamines as anion transporters. We have found that these compounds and synthetic analogues are potent anion transporters and that their biological activity correlates well with their anion transport properties.
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Papers共 114 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of clinical and experimental dentistryno. 2 (2023): e125-e134
crossref(2023)
iScienceno. 10 (2023): 107898-107898
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