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个人简介
My laboratory studies mechanisms of inflammatory responses relevant to airway diseases characterized by inflammation and mucin overproduction, e.g., asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD). During the last few years, we have investigated the role of alterations in calcium signaling for inflammatory responses relevant to CF, and the importance of mitochondria in restricting calcium-mediated functions in polarized airway epithelia. We also study the role of the Unfolded Protein Response (UPR) in airway inflammatory responses. We were the first to implicate the UPR pathway mediated by the ubiquitous inositol requiring enzyme 1α (IRE1α) in cytokine production by human bronchial epithelia (http://www.ncbi.nlm.nih.gov/pubmed/19321437), and made the key discovery that the isoform IRE1β is only expressed in mucous cells and is required for airway epithelial mucin production (http://www.ncbi.nlm.nih.gov/pubmed/23168839). We are currently investigating the functional role of additional branches of the UPR in other aspects of pulmonary inflammation (http://www.ncbi.nlm.nih.gov/pubmed/21030518; http://www.ncbi.nlm.nih.gov/pubmed/22697344), and in cigarette smoke-induced alterations in airway epithelial function.
研究兴趣
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American journal of respiratory and critical care medicineno. 4 (2024): 374-389
Alexandra P M Cloherty,Anusca G Rader, Kharishma S Patel,Tracy-Jane T H D Eisden, Sterre van Piggelen,Renée R C E Schreurs,Carla M S Ribeiro
Frontiers in immunology (2024): 1260439-1260439
Nienke H van Teijlingen, Marleen Y van Smoorenburg,Ramin Sarrami-Forooshani,Esther M Zijlstra-Willems,John L van Hamme,Hanneke Borgdorff,Janneke Hhm van de Wijgert,Elisabeth van Leeuwen, Joris A M van der Post,Karin Strijbis,Carla M S Ribeiro,Teunis B H Geijtenbeek
The Journal of infectious diseases (2024)
Renee R. C. E. Schreurs, Athanasios Koulis,Thijs Booiman,Brigitte Boeser-Nunnink,Alexandra P. M. Cloherty,Anusca G. Rader, Kharishma S. Patel,Neeltje A. Kootstra,Carla M. S. Ribeiro
NATURE COMMUNICATIONSno. 1 (2024): 2465-2465
Y. Mikami,C. van Heusden,H. Dang, E. Burns,C.M.P. Ribeiro,R.C. Gilmore, K. Okuda,S.H. Randell,W.K. O'Neal,R.C. Boucher
B31. AIRWAY EPITHELIAL INFLAMMATION AND DYSFUNCTION (2024)
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 5 (2023): 5010-5010
Renée Schreurs, Athanasios Koulis,Thijs Booiman,Brigitte Boeser‐Nunnink,Alexandra Cloherty,Anusca G. Rader, Kharishma Patel,Neeltje A. Kootstra,Carla M. S. Ribeiro
Research Square (Research Square) (2023)
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