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Current main project is to investigate the role of genetic variation in the ADHD risk gene ADGRL3 in disease development. This project involves the generation and characterisation of human induced pluripotent stem cells (hiPSCs) from healthy and ADHD patient-derived fibroblast cells, which carry different single nucleotide polymorphisms (SNPs) in the ADGRL3 gene. hiPSCs are then differentiated into cortical neurons and characterised for cell type-specific markers, and ADGRL3 expression analysed to determine whether SNPs can alter expression. Functional analyses are also performed, such as calcium imaging and electrophysiology, to determine the potential downstream effects of genetic variation.
Position includes supervision of PhD, Masters and Bachelors students, and teaching for Translational Neuroscience MSc program.
Research Interests
Papers共 29 篇Author StatisticsCo-AuthorSimilar Experts
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Therapeutic drug monitoringno. 2 (2024): 195-202
Molecular Psychiatrypp.1-3, (2024)
Cristine Marie Yde Ohki,Rhiannon V McNeill,Anthony C Vernon,Erik Smedler,Tanja Maria Michel,Michael Peitz, Marie-Claude Potier,Sarah Kittel-Schneider,Edna Grünblatt, members of the iPSC Platform for Neuropsychiatry ECNP Network
Molecular psychiatry (2024)
crossref(2024)
Neuroscience Applied (2023): 101125-101125
Stem cell research (2023): 103016-103016
Franziska Radtke,Viola Stella Palladino,Rhiannon V McNeill,Andreas G Chiocchetti,Denise Haslinger, Matthias Leyh, Danijel Gersic,Markus Frank,Lena Grünewald,Stephan Klebe,Oliver Brüstle,Katharina Günther,
Brain, behavior, and immunity (2022): 275-283
Research Square (Research Square) (2022)
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