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个人简介
I have a background in Nanotechnology and Nanomedicine, and I have developed my expertise in biomedical engineering and bioengineering through my extensive research in the field of drug and gene delivery. My research includes developing nanoformulations for CRISPR gene editing technology. During my postdoctoral period, I developed a patented nanoformulation for targeted CRISPR gene editing in hematopoietic stem cells (HSCs) which is currently one of the best candidates for the in vivo gene editing applications. As a PI on Fred Hutchinson’s Evergreen funding opportunity, I developed my skills in aptamer library screenings through my work on finding highly specific aptamers to target HSCs. In addition, I have gained specific expertise in synthesis, bioconjugation, and surface modification of nanomaterials through my Ph.D. and postdoctoral research. My primary goal has always been to develop non-toxic and safe therapeutics for the clinical treatment of different malignancies. In this regard, through my Ph.D. work, I developed surface modified gold nanoparticles and showed that these nanoparticles can be used in theranostic applications for imaging and nucleolar targeting of neuronal cells. Also, I developed surface modified gold nanoparticles for in vivo delivery of siRNAs to tumor tissue in triple negative breast cancer and I showed that mice tumor models were successfully treated with only once a week injection of developed gold based siRNA nano-therapeutics in four weeks.
研究兴趣
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Journal of Clinical Oncologyno. 16_suppl (2024): 1603-1603
International journal of pharmaceutics (2024): 124057-124057
Reza Shahbazi,Daniel Douglas Lane, Patricia Lipson,Karthikeya Gottimukkala,Rachel Cunningham, Molly Ellena Cassidy, Youngseo Jwa,Jennifer E. Adair
MOLECULAR THERAPYno. 4 (2023): 16-16
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MOLECULAR THERAPYno. 4 (2023): 494-495
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Frontiers in bioengineering and biotechnology (2023): 1288806
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