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个人简介
Dr Tooze is an academic haematopathologist combining active clinical work in an specialist diagnostic centre for haematopathology, with running a research lab focusing on the relationships between B-cell terminal differentiation and the pathology of related malignancies. The principal focus is on the factors regulating the formation and maintenance of human plasma cells and the underlying transcriptional programmes driving this process. The lab employs in vitro model systems allowing the generation and maintenance of long-lived plasma cells to study these questions.
Dr Tooze trained in histopathology and undertook a PhD in Immunology under Prof Douglas T. Fearon, FRS in Cambridge (UK). During this time he met and published with his wife and co-investigator Dr Gina Doody. Following completion of specialist training Dr Tooze committed exclusively to haematopathology, working at the Haematological Malignancy Diagnostic Service (HMDS http://www.hmds.info/) of the Leeds Teaching Hospitals NHS Trust.
Dr Tooze was awarded an MRC Clinician Scientist Fellowship in 2003, followed in 2008 by award of a CRUK Senior Clinical Fellowship aimed at understanding the transcriptional complexity of terminal B-cell differentiation and its relationship to lymphoma.
研究兴趣
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LEUKEMIAno. 2 (2024): 372-382
Research Square (Research Square)no. 3 (2024): 621-629
CANCER EPIDEMIOLOGY (2024): 102513-102513
Panagiota Vardaka, Eden Page,Matthew A Care,Sophie Stephenson, Ben Kemp, Michelle Umpierrez, Eleanor O’Callaghan, Adam Mabbutt,Roger Owen,Daniel J Hodson,Gina M Doody,Reuben M Tooze
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Blood Advancesno. 15 (2023): 3874-3890
BRITISH JOURNAL OF HAEMATOLOGY (2023): 64-64
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John R Davies,Laura K Hilton,Aixiang Jiang,Sharon L Barrans,Catherine Burton,Peter W M Johnson, Andrew John Davies,Ming-Qing Du,Reuben M Tooze,Francesco Cucco,Matthew A Care,Ryan D Morin,
JOURNAL OF CLINICAL ONCOLOGYno. 15 (2023): 2718-+
crossref(2023)
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