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I cruised along for a while, then, about 15 years ago, I stumbled
on a pearl necklace, or, at least, a necklace of some value, and that
was the type 1 insulin-like growth factor receptor (IGF-IR from now
on). I was looking at genes that transformed cells, and I found that
when 3T3 cells expressed both the IGF-IR and its ligand, IGF-1,
they grew in serum-free medium and actually formed tumors in
mice. That attracted my interest and soon after we had a real break.
Argyris Efstratiadis had just reported that mouse embryos with a
targeted disruption of the IGF-I receptor genes were 50% in size, in
respect to wild type littermates. Just out of curiosity, I asked him to
borrow a few of his mutant embryos to develop a cell line without
IGF-1 receptors. Since his results are reproducible, Arg was not
afraid to give out his mice or his reagents, and sent us some embryos.
on a pearl necklace, or, at least, a necklace of some value, and that
was the type 1 insulin-like growth factor receptor (IGF-IR from now
on). I was looking at genes that transformed cells, and I found that
when 3T3 cells expressed both the IGF-IR and its ligand, IGF-1,
they grew in serum-free medium and actually formed tumors in
mice. That attracted my interest and soon after we had a real break.
Argyris Efstratiadis had just reported that mouse embryos with a
targeted disruption of the IGF-I receptor genes were 50% in size, in
respect to wild type littermates. Just out of curiosity, I asked him to
borrow a few of his mutant embryos to develop a cell line without
IGF-1 receptors. Since his results are reproducible, Arg was not
afraid to give out his mice or his reagents, and sent us some embryos.
研究兴趣
论文共 132 篇作者统计合作学者相似作者
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Growth Control During Cell Agingpp.19-29, (2020)
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