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Research Interests
My laboratory is interested to understand how extracellular factors control the fate of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs). We have elucidated regulation of key pluripotency factor NANOG, epigenetic modifiers DNMT3B and JMJD1C, apoptotic factor Caspase 3, and cell membrane transporter ABCG2 by BMP, TGFb and/or FGF signaling in hESCs. We are also interested in exploring novel approaches to developing stem cell therapies, and have recently demonstrated that mesenchymal stem cells derived from hESCs (hES-MSCs) using innovative methods significantly reduce the severity of disease in an animal model of multiple sclerosis, and that hES-MSCs offer much better efficacy than human bone marrow derived MSCs that are currently being tested in clinical trials for multiple sclerosis and other autoimmune diseases. Our current research interests include:
Optimised generation and maintenance of human embryonic stem cell-derived mesenchymal stem cells (hES-MSCs)
Therapeutic application of hES-MSCs
Marfan syndrome modelled with induced pluripotent stem (iPS) cells
Research Interests
Papers共 87 篇Author StatisticsCo-AuthorSimilar Experts
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Ye Yi, Guihui Qin,Hongmei Yang,Hao Jia, Qibing Zeng,Dejin Zheng, Sen Ye, Zhiming Zhang,Tzu-Ming Liu,Kathy Qian Luo,Chu-Xia Deng,Ren-He Xu
Advanced science (Weinheim, Baden-Wurttemberg, Germany)no. 21 (2024): e2400888-e2400888
SMALLno. 1 (2024)
NATURE BIOTECHNOLOGYno. 4 (2024): 563-569
Tissue engineering. Part Ano. 17-18 (2023): 491-505
Min Chen,Zaoxu Xu,Yu Chen,Qingyang Yang,Ruiqing Lu,Yankai Dong,Xiaosong Li,Jundong Xie,Ren-He Xu, Haidong Jia, Yan Kang,Yaojiong Wu
Yumeng Zhang, Ye Yi,Xia Xiao,Lingling Hu,Jiaqi Xu,Dejin Zheng, Ho Cheng Koc,Un In Chan,Ya Meng,Ligong Lu,Weiwei Liu,Xiaoling Xu,
Communications Biologyno. 1 (2023): 1-11
Journal of Medical Virologyno. 2 (2023): e28354-e28354
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