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Integrins are cell surface receptors that link proteins of the extracellular matrix with the actin cytoskeleton. The ligand binding property of integrins requires an activation step that is characterized by a conformational change of the ectodomain, separation of the transmembrane and cytoplasmic domains and the opening of the ligand binding pocket.
Integrins are cell surface receptors that link proteins of the extracellular matrix with the actin cytoskeleton. The ligand binding property of integrins requires an activation step that is characterized by a conformational change of the ectodomain, separation of the transmembrane and cytoplasmic domains and the opening of the ligand binding pocket.
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crossref(2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 26 (2023)
Nature Structural & Molecular Biologyno. 12 (2023): 1913-1924
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 31 (2023): e2301881120-e2301881120
Nature communicationsno. 1 (2023): 2143-17
biorxiv(2022)
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