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Dr. Koehler is conducting basic and preclinical translational research in the areas of cerebrovascular physiology and cerebral ischemic injury that arises from stroke and cardiac arrest. His lab uses the filament model of transient middle cerebral artery occlusion to investigate physiologic and pathophysiologic mechanisms that underlie stroke. It is already known that the formation of reactive oxygen species after stroke damages DNA, which leads to the activation of poly(ADP-ribose) and formation of poly(ADP-ribose) polymers. In partnership with researchers in the Institute of Cell Engineering at Johns Hopkins, Dr. Koehler and his colleagues are investigating how release of these polymers from the nucleus triggers the release of apoptosis-inducing factors from the mitochondria and causes neuronal cell death.
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Frontiers in medical technology (2023): 1074643-1074643
JOURNAL OF NEUROTRAUMAno. 15-16 (2023): A39-A39
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Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolismno. 11 (2023): 1842-1856
Journal of neurotraumano. 11-12 (2023): 1197-1215
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Aditi Vichare,Javier AllenDe labastida,Sophia Newton, Kaitlyn Tingus,Afshin Paydar,Jonathan Tong,Annika Myers,Raymond Koehler,Jieru Wan,Timothy Van Meter,Kevin Wang,Jiepei Zhu,
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Science translational medicineno. 714 (2023): eadg8656-eadg8656
Christopher T. Primiani,Jennifer K. Lee,Caitlin E. O'Brien,May W. Chen,Jamie Perin,Ewa Kulikowicz,Polan Santos,Shawn Adams, Bailey Lester, Natalia Rivera-Diaz, Valerie Olberding,Mark V. Niedzwiecki,
Cellsno. 20 (2023): 2454-2454
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Marcelo Febo,Marjory Pompilus,Jiepei Zhu, Zoyu Wu, Daniel Arja,Zhihui Yang,Firas Kobeissy,Ina Wanner,Neil Harris,Raymond Koehler,Jinyuan Zhou,Mark Burns,
JOURNAL OF NEUROTRAUMAno. 15-16 (2023): A134-A134
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Ina Wanner, Kaitlyn Tingus,Afshin Paydar,Jonathan Tong, Aditi Vichare,Annika Myers,Sophia Newton,Javier Allende labastida,Raymond Koehler,Jieru Wan,Timothy Van Meter,Kevin Wang,
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