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职业迁徙
个人简介
Research Area:
Epilepsy; Genetic control of glutamate receptor function
Research Interests:
Glutamate receptors mediate the vast majority of excitatory synaptic transmission in the brain. A major research effort is focused on regulation of glutamate receptor-mediated synaptic transmission in the brain by the co-activation of selected G-protein coupled receptors. A second research emphasis involves the use of microarray and associated technologies to identify novel targets and pathways involved in the basic cellular and molecular mechanisms of epilepsy. These research interests converge and have highlighted a role for cyclooxygenase-2 (COX2) signaling pathways in the cognitive deficits, impaired synaptic inhibition, and eurodegeneration caused by seizures. We are currently exploring the consequences of conditional COX2 knockouts and are seeking the prostaglandin receptors responsible for each of these effects; we are employing a chemical biology approach to develop novel small molecule modulators of these receptors in an effort to interrupt the development of epilepsy. As a whole our work integrates information from a variety of experimental strategies to contribute to a better understanding of epilepsy, with broad implications for other brain disorders including stroke and schizophrenia.
研究兴趣
论文共 131 篇作者统计合作学者相似作者
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EPILEPSY CURRENTSno. 1 (2024): 53-55
Olga Taraschenko,Howard S. Fox,Ember Eldridge, Priscilla Heliso,Fetweh Al-Saleem,Scott Dessain,George Casale,Gregory Willcockson, Kayley Anderson,Wenyi Wang,Raymond Dingledine
EPILEPSIA (2024)
Olivia R Hoffman,Anna Patterson,Emily Gohar,Emanuel Coleman, Jose Ezekial Clemente Espina,Barry Schoenike,Claudia Espinosa-Garcia,Felipe Paredes,Raymond Dingledine,Jamie Maguire,Avtar Roopra
bioRxiv : the preprint server for biology (2023)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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T. Cameron Tran, Blossom Sneed, Jamil Haider, Delali Blavo, Audrey White, Temitope Aiyejorun, Timothy C. Baranowski,Amy L. Rubinstein, Thanh N. Doan,Raymond Dingledine,Eric M. Sandberg
crossref(2023)
Olivia R. Hoffman, Anna M. Patterson,Emily S. Gohar,Emanuel Coleman,Barry A. Schoenike,Claudia Espinosa-Garcia,Felipe Paredes,Raymond J. Dingledine,Jamie L. Maguire,Avtar S. Roopra
biorxiv(2023)
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
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