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We work on how the body responds to hypoxia, or low levels of tissue oxygen. This is relevant to a number of diseases, including cancer, and the laboratory is interested in hypoxic response in disease as well as in normal physiology.
The response to hypoxia acts in significant part through the Hypoxia Inducible Factor, or HIF. The actions of this transcription factor are evident in almost all forms of cancer, but HIF is also present in other disease states. Further, many aspects of normal physiological response include activation of HIF: HIF expression is seen in normal embryonic development, it is seen whenever wound healing or inflammation occur, and is essential for adjustment to high altitude or whenever the organism experiences a lower than normal level of oxygen.
The response to hypoxia acts in significant part through the Hypoxia Inducible Factor, or HIF. The actions of this transcription factor are evident in almost all forms of cancer, but HIF is also present in other disease states. Further, many aspects of normal physiological response include activation of HIF: HIF expression is seen in normal embryonic development, it is seen whenever wound healing or inflammation occur, and is essential for adjustment to high altitude or whenever the organism experiences a lower than normal level of oxygen.
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crossref(2023)
Brennan J Wadsworth, Marina Leiwe,Eleanor A Minogue,Pedro P Cunha,Viktor Engman,Carolin Brombach, Christos Asvestis,Shiv K Sah-Teli, Emilia Marklund,Peppi Koivunen,Jorge L Ruas,Helene Rundqvist,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2022)
Cell Reportsno. 9 (2022): 113013-113013
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