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Bio
She was among the first to discover the role of epigenetic changes and noncoding RNAs in promoting diabetic micro- and macrovascular complications. Her team identified specific chromatin histone post-translational modifications and DNA methylations that drive inflammatory and fibrotic genes in diabetes. Her studies in this area provided clinical evidence that persistent epigenetic changes are associated with the phenomenon of “metabolic memory” in which periods of prior high blood sugar levels predispose diabetic patients to long-term vascular complications, despite subsequent optimum glucose control. These findings have led to a new appreciation of the connections between glycemic history, epigenetics, metabolic memory and diabetic vasculopathy. Dr. Natarajan also evaluates translational approaches targeting epigenetic changes and non-coding RNAs for the treatment of diabetic complications. She has published over 200 papers and has received numerous awards. Her studies have been continuously funded by the National Institutes of Health for 30 years.
Research Interests
Papers共 446 篇Author StatisticsCo-AuthorSimilar Experts
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Diabetesno. 4 (2024): 611-617
Naseeb Kaur Malhi,Yingjun Luo,Xiaofang Tang, Rahuljeet Singh Chadha,Alonso Tapia,Xuejing Liu, Muxi Chen,Dongqiang Yuan,Meirigeng Qi, Lu Wei,John P Cooke,Rama Natarajan,
bioRxiv : the preprint server for biology (2024)
American journal of physiology. Renal physiology (2024)
crossref(2024)
Molecular Therapy - Nucleic Acidspp.102252, (2024)
Zhuo Chen,Eiichiro Satake,Marcus G Pezzolesi,Zaipul I Md Dom, Devorah Stucki,Hiroki Kobayashi,Anna Syreeni, Adam T Johnson,Xiwei Wu,Emma H Dahlström, Jaxon B King,Per-Henrik Groop,
Science translational medicineno. 748 (2024): eadj3385-eadj3385
Arteriosclerosis, Thrombosis, and Vascular Biologyno. Suppl_1 (2023)
Arteriosclerosis, Thrombosis, and Vascular Biologyno. Suppl_1 (2023)
Nikita Wright,Yuan Yate-Ching, Tijana Talisman,Rama Natarajan,Mark LaBarge,Padmashree Rida,Victoria Seewaldt
Cancer Epidemiology, Biomarkers & Preventionno. 1 (2023): 267-268
crossref(2023)
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