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个人简介
The Kleiner lab studies the function and regulation of cellular RNA using the tools of chemical biology. RNA is a central molecule in biology that controls the flow of genetic information, and its behavior is regulated by a diversity of chemical and biochemical mechanisms with important roles in health and disease. Our lab focuses on investigating the post-transcriptional regulation of RNA function by interactions with RNA-binding proteins (RBPs) and chemical “epitranscriptomic” modifications to the canonical nucleotides. Additionally, we have developed broadly applicable chemical tools for measuring cellular RNA synthesis and turnover, localization, and structure. All projects involve a mix of chemical and biological methods and span in vitro and cellular/organismal systems.
研究兴趣
论文共 39 篇作者统计合作学者相似作者
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Ku-Lung Hsu,Anthony M. Ciancone, Kyung W. Seo, Miaomiao Chen,Adam L. Borne,Adam H. Libby,Dina L. Bai,Ralph E. Kleiner
Cancer Researchno. 7_Supplement (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Cell chemical biologyno. 8 (2023): 906-919.e4
ACS chemical biologyno. 8 (2023): 1684-1697
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CELL CHEMICAL BIOLOGYno. 8 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv : the preprint server for biology (2023)
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Accounts of chemical researchno. 19 (2023): 2726-2739
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