基本信息
浏览量:82
职业迁徙
个人简介
Scientific Achievments (Selection):
1989 Genetic screen, which led to the identification of peroxins.
1991 Pex1p, the first peroxin Pex1p and discovery of AAA-proteins as novel family of ATPases.
1995 Proteomic screen for the identification of peroxisomal membrane proteins.
1994 Pex7p, the import receptor for peroxisomal PTS2-proteins.
1995 Model of cycling receptors.
1995 Pex11p as first peroxin, required for peroxisome proliferation.
1995 Pex13p, the first docking protein of the peroxisomal import machinery.
1997 Pex14p, point of convergence of PTS1- and PTS2-dependent peroxisomal protein import.
1998 IDP3, produces NADPH for peroxisomal degradation of unsaturated fatty acids.
2000 Pex8p, novel component of the peroxisomal import machinery.
2001 Ant1, the first peroxisomal ATP-transporter.
2002 Identification of the targeting signal for peroxisomal membrane proteins
2004 Poly-Ubiquitination of the PTS1-import receptor
2005 Function of Pex1p/Pex6p in the ATP-dependent receptor recycling
2005 The Transient Pore Model.
2007 Mono-ubiquitination as signal for ATP-dependent receptor export and recycling.
2009 Elucidation of the PTS1-ubiquitination pathway (Function of Pex4p and Pex12p).
2010 Identification of the translocation pore of the PTS1-import machinery.
2010 Peroxisomal protein import and ERAD; The Export-driven Import Model.
2011 Role of Ubp15p in deubiquitination and recycling of peroxisomal import receptor Pex5p.
2012 Pex14p-dependent movement of peroxisomes along microtubules.
2013 Elucidation of the Ubiquitination pathway in peroxisomal import of PTS2-proteins.
2015 Structure of Pex1p.
2015 Identification of the PTS2-import pore, distinct pores for PTS1- and PTS2-proteins.
2015 Stress-regulated novel import pathway for PTS2-proteins.
2016 Pex9p, a novel import receptor for PTS1-proteins.
2017 Developments of a new line of drugs against sleeping sickness and Chagas disease.
研究兴趣
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