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Bio
Research Focus
My research focuses on the role of the vasculature and blood in aggressiveness and progression of human cancers, especially in the brain, kindey and hematopoietic system. We study how angiogenic and clotting factors influence the malignant disease and how to treat tumours more effectively using agents targeting vascular abnormalities. We described cancer-induced vascular processes that are distinct in adult and children. We also focus on cancer-specific interactions between tumour cells and vascular cells by exchange of unique cellular fragments known as extracellular vesicles or exosomes, some of which contain cancer causing genes and regulatory proteins and can serve as unprecedented sources of diagnostic information in cancer. We believe that interruption of intercellular connections represents a new frontier in therapy of human malignancies.
My research focuses on the role of the vasculature and blood in aggressiveness and progression of human cancers, especially in the brain, kindey and hematopoietic system. We study how angiogenic and clotting factors influence the malignant disease and how to treat tumours more effectively using agents targeting vascular abnormalities. We described cancer-induced vascular processes that are distinct in adult and children. We also focus on cancer-specific interactions between tumour cells and vascular cells by exchange of unique cellular fragments known as extracellular vesicles or exosomes, some of which contain cancer causing genes and regulatory proteins and can serve as unprecedented sources of diagnostic information in cancer. We believe that interruption of intercellular connections represents a new frontier in therapy of human malignancies.
Research Interests
Papers共 423 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
NATURE COMMUNICATIONSno. 1 (2024): 2865-2865
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRYno. 1 (2024): 2290910-2290910
JOURNAL OF THROMBOSIS AND HAEMOSTASISno. 1 (2024): 3-6
Bleeding, Thrombosis and Vascular Biologyno. s1 (2024)
crossref(2023)
Book of Abstracts (2023)
FRONTIERS IN MEDICINE (2023): 1252417-1252417
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Author Statistics
#Papers: 428
#Citation: 29506
H-Index: 70
G-Index: 165
Sociability: 8
Diversity: 4
Activity: 149
Co-Author
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