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个人简介
My lab is broadly interested in the mechanisms of signaling and transport across cellular membranes. Our research encompasses several protein families: Nramp transporters that use a proton gradient to facilitate the entry of divalent ions (iron and manganese in particular) into cells; non-classical cadherins involved in cellular adhesion and signaling; ABC transporters that use ATP to fuel substrate transport; and TRP channels important to sensing temperature and painful stimuli. We use a variety of cell-based and in vitro biochemical assays, x-ray crystallography, and computational techniques (molecular dynamics simulations and bioinformatics analyses) to discover how these important proteins function in cells. Below are brief descriptions that illustrate our approaches and goals for specific projects.
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Cell Reportsno. 4 (2024): 114035-114035
bioRxiv : the preprint server for biology (2024)
EMPIAR dataset (2023)
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Biochemical Society transactionsno. 3 (2023): 897-923
Biochimie (2023): 124-135
EMPIAR dataset (2023)
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