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Neuronal circuits typically exhibit stereotypic wiring patterns that are designed for specific functions. Our lab’s major focus is to understand the developmental mechanisms that shape synaptic connectivity in the central nervous system, using the vertebrate retina as our model system.
We have developed and applied cellular and synaptic labels to visualize circuits in vivo and in vitro, largely through biolistics and transgenic approaches. Correlative fluorescence and serial electron microscopy enable us to map identified synaptic connections onto individual neurons. Both normal and perturbed cell functions are probed using electrophysiological techniques including whole-cell and multielectrode array recordings. We are currently investigating the cellular mechanisms and developmental strategies that establish excitatory and inhibitory circuits in the mammalian retina. By taking advantage of the zebrafish’s capacity to regenerate neurons, we are also determining how newly-generated neurons integrate into existing circuitry.
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Papers共 265 篇Author StatisticsCo-AuthorSimilar Experts
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AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science (2024): 334-343
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Guek Nee Ke,Alan Gow,Rachel Mei Ming Wong, Shahirah Raman, Zulaikha Mohammad, Nicole De-Lima,Rozainee Khairudin,Wee Yeap Lau,Khalil Anwar Kamal, Shen Chiang Lee,Dasha Grajfoner
Neha Reddy, Steve Johnson,Richard A. Moffitt,Michael Evans,Hsin-Chieh Yeh,Jane E. B. Reusch,Rachel Wong,John B. Buse,Carolyn Bramante,Jeremy Harper
DIABETES (2023)
Elena Casiraghi, on behalf of the NC Consortium,Rachel Wong,Margaret Hall,Ben Coleman,Marco Notaro,Michael D. Evans,Jena S. Tronieri,Hannah Blau,Bryan Laraway,Tiffany J. Callahan,Lauren E. Chan,
Journal of Biomedical Informatics (2023)
Current Diabetes Reportsno. 8 (2023): 207-216
Journal of visionno. 15 (2023): 2-2
Journal of the American Medical Informatics Association : JAMIAno. 7 (2023): 1284-1292
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