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My broad research expertise is in inorganic chemical biology and medicinal chemistry. I study the inorganic chemical biology of a class of bacterial metabolites known as siderophores that have a high affinity towards iron(III) and other metal ions of relevance to biomedicine and biomedical imaging. The siderophore that we study most extensively is desferrioxamine B (DFOB), which is one of three clinical agents used to treat secondary iron overload occuring in people with inherited transfusion-dependent blood disorders. My cross-discipline research traverses chemistry (inorganic, organic, and medicinal), biochemistry, microbiology and biotechnology. My group has developed a water-compatible method in affinity chromatography to select for clinical bacterial metabolites from complex fermentation mixtures. This method is particularly successful for the streamlined isolation of bacterial siderophores and for the anticancer agent doxorubicin, and could have potential for green chemistry processing of pharmaceutics. This analytical method has allowed us to map low-abundant siderophore metabolomes in marine and terrestrial bacteria and is being extended in a drug discovery context.
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Papers共 106 篇Author StatisticsCo-AuthorSimilar Experts
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Todd E. Markham,Rachel Codd
Jenny Ni, James L. Wood,Melanie Y. White,Norbert Lihi, Todd E. Markham, Joseph Wang,Peter T. Chivers,Rachel Codd
European Journal of Nuclear Medicine and Molecular Imagingno. 12 (2022): 4037-4047
Reference Module in Chemistry, Molecular Sciences and Chemical Engineeringpp.3-29, (2021)
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