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I am interested in the molecular mechanisms of microbial pathogenesis, particularly the mechanisms that allow colonization and carriage of Bordetella pertussis.、
My laboratory also studies a family of bacterial surface proteins that represent a large class of virulence factors in Gram-negative bacteria, including B. pertussis. These proteins, called autotransporters, appear to encode their own channel to enable them to cross the bacterial outer membrane. How this happens is the subject of much debate.
My laboratory seeks to:
Understand the mechanisms by which B. pertussis resists the complement pathway
Determine the mechanism by which B. pertussis modifies its lipid A with glucosamine and how this impacts pathogenesis
Elucidate the mechanisms by which the autotransporter family of proteins are secreted by the bacterium
I am interested in the molecular mechanisms of microbial pathogenesis, particularly the mechanisms that allow colonization and carriage of Bordetella pertussis.、
My laboratory also studies a family of bacterial surface proteins that represent a large class of virulence factors in Gram-negative bacteria, including B. pertussis. These proteins, called autotransporters, appear to encode their own channel to enable them to cross the bacterial outer membrane. How this happens is the subject of much debate.
My laboratory seeks to:
Understand the mechanisms by which B. pertussis resists the complement pathway
Determine the mechanism by which B. pertussis modifies its lipid A with glucosamine and how this impacts pathogenesis
Elucidate the mechanisms by which the autotransporter family of proteins are secreted by the bacterium
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TRENDS IN MICROBIOLOGYno. 11 (2023): 1192-1193
Trends in microbiologyno. 11 (2023): 1192-1193
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