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Roger Sturmey (RS) is a jointly appointed Senior Lecturer of Reproductive Medicine at the Hull York Medical School and at The University of Manchester. He has a varied
research portfolio, which asks how cellular metabolism influences cell physiology in a variety of
biological systems, and can be broadly described as Developmental Metabolism; how metabolic
activity drives, and responds to cell development. His core research area is focussed on how the
periconceptual environment can change the physiology and metabolic regulation of early embryos
and how this might persist into the offspring. He has been actively researching metabolic regulation
during early development for almost 15 years, and his work has contributed in a major way to our
understanding of the wider role of energy metabolism in early development, with particular emphasis
on the glucose:fatty acid metabolic axis. He is also interested in how the environment in the Fallopian
Tube formed, and has developed a novel model that can mimic the oviductal lumen.
During his PhD, RS was the first to report that mammalian oocytes have a requirement for fatty acid
oxidation; a discovery subsequently confirmed by other researchers globally, and has continued to
examine how the metabolic phenotype of an oocyte and embryo impacts on subsequent
development. After his PhD, he undertook post doctoral training, first in Leeds (on DNA damage in
oesophageal cancer), before returning to York where he was subsequently awarded a University/
Wellcome VIP Fellowship, during the tenure of which he identified a direct association between
amino acid metabolism and DNA damage in early embryos (Sturmey et al (2009) Hum Rep). In
addition to this, and together with Dr Jo Leroy (Antwerp), he has made significant advances in
understanding the mechanism by which exposing oocytes to a high fat environment can lead to
metabolic and genetic reprogramming of the resulting early embryo post fertilisation (Van Hoeck et al
(2011), PLoS One, Van Hoeck (2013), et al Reprod). More recently, working with Professor Marc-
Andre Sirard (University of Laval, Canada) he has generated data demonstrating that the epigenetic
profile of an embryo is shaped by the metabolic activity of the embryo on day 2-3 of development;
findings echoed in work carried out in collaboration with Dr John Huntriss (Huntriss et al (2013)
Eu J Hum Gen). Furthermore, he has identified that the early embryos of women who are
overweight and obese are metabolically compromised, containing significantly more fat than
embryos form healthy weight women. These research discoveries have been underpinned by
unique expertise in metabolic assays at the nano scale in single embryos, somatic and stem cells
(e.g. Geurif et al PLoS One (2013)); metabolic profiling technology with is combined with proficiency
in techniques for imaging mitochondrial activity and localisation in live cells (Sturmey et al Reprod
(2006)). This skill set led to the award of an MRC Translational Stem Cell Research grant, which
has uncovered putative novel non-invasive biomarkers of hESC and induced pluripotent stem cell
pluripotency (work ongoing). His reputation for studying cellular metabolism within the field of
Reproductive Medicine has led to numerous invitations to give plenary presentations at national and
international conferences. His laboratory is now translating these techniques to other cellular
systems, including platelets in collaboration with Professor Khalid Naseem (HYMS), T-cells, in
collaboration with Dr Mark Cragg (Southampton) on an NC3Rs Crack-it programme, and more
recently, Mesenchymal Stem Cells (MSCs) in collaboration with Paul Genever and Paul Pryor at the
University of York.
He works closely with colleagues at the Hull IVF Unit where he is Nominal Licensee on a HFEA
Research Licence. In addition to teaching duties at the Hull York Medical School, he is a member of
the Scientific Advisory Committee for the Association of Clinical Embryologists. His laboratory uses a range of techniques including ultramicrofluorescent assays of substrate
concentration, sufficiently sensitive to determine metabolic activity on a single cell scale. In
addition, RGS lab has the only working nanorespiromter in the UK; this device enables singlecell
determination of oxygen depletion. Furthermore there are extensive LC capabilities with
established assays to measure amino acids, ascorbic acid, GSH:GSSG, TBARS and tocopherol,
with significant method development expertise to develop new assays for substrate depletion/
accumulation. Finally, there are extensive facilities for the in vitro generation of mammalian
embryos, under various conditions to mimic physiological and pathophysiological milieux.
Research Interests
Papers共 108 篇Author StatisticsCo-AuthorSimilar Experts
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Israel O. Bolanle,Gillian A. Durham, James P. Hobkirk,Mahmoud Loubani,Roger G. Sturmey,Timothy M. Palmer
Diabetologyno. 2 (2024): 162-177
Journal of Assisted Reproduction and Geneticsno. 6 (2024): 1-6
Nature cell biologyno. 12 (2023): 1717-1719
NATURE CELL BIOLOGYno. 12 (2023): 1884-1884
Nature Cell Biologyno. 12 (2023): 1884-1884
Fertility and sterilityno. 6 (2023): 1151-1159
Development (Cambridge, England)no. 17 (2023)
Development (Cambridge, England)no. 20 (2023)
BRITISH JOURNAL OF PHARMACOLOGY (2023): 116-117
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