基本信息
views: 7
Career Trajectory
Bio
Research Area: Neurophysiology
Research Description:
We are interested in understanding the molecular bases of mechanotransduction, and the role of mechanosensory neurons in normal and pathological pain transmission. Mechanotransduction, the process through which cells convert a mechanical stimulus into an electrical signal, is of fundamental importance to physiological functions such as our senses of touch (including pain) and hearing, as well as our ability to regulate our hydromineral homeostasis (thirst), baroreflex function and myogenic tone (regulation of blood pressure). Mechanosensitive ion channels are membrane proteins responsible for most mechanotransduction processes, yet their molecular identity has not been fully resolved. Because these channels are involved in several pathologies of the nervous (chronic pain, deafness) and cardiovascular (hypertension) systems, the molecular identification of these channels, and understanding their activation properties may lead to the development of new therapeutic strategies in several clinical areas.
The projects in the lab focus on two areas of research:
1) Identification of the molecular mechanisms underlying neuronal mechanotransduction.
2) Identification of central (spinal cord) neuronal circuits engaged by mechanosensory afferents in control or during chronic pain conditions.
Research Description:
We are interested in understanding the molecular bases of mechanotransduction, and the role of mechanosensory neurons in normal and pathological pain transmission. Mechanotransduction, the process through which cells convert a mechanical stimulus into an electrical signal, is of fundamental importance to physiological functions such as our senses of touch (including pain) and hearing, as well as our ability to regulate our hydromineral homeostasis (thirst), baroreflex function and myogenic tone (regulation of blood pressure). Mechanosensitive ion channels are membrane proteins responsible for most mechanotransduction processes, yet their molecular identity has not been fully resolved. Because these channels are involved in several pathologies of the nervous (chronic pain, deafness) and cardiovascular (hypertension) systems, the molecular identification of these channels, and understanding their activation properties may lead to the development of new therapeutic strategies in several clinical areas.
The projects in the lab focus on two areas of research:
1) Identification of the molecular mechanisms underlying neuronal mechanotransduction.
2) Identification of central (spinal cord) neuronal circuits engaged by mechanosensory afferents in control or during chronic pain conditions.
Research Interests
Papers共 57 篇Author StatisticsCo-AuthorSimilar Experts
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Cell reports methodsno. 6 (2024): 100791-100791
Shamsuddin A Bhuiyan,Mengyi Xu,Lite Yang, Evangelia Semizoglou,Parth Bhatia, Katerina I Pantaleo,Ivan Tochitsky,Aakanksha Jain,Burcu Erdogan,Steven Blair, Victor Cat,Juliet M Mwirigi,
Haoyi Qiu,Loïs S Miraucourt,Hugues Petitjean,Mengyi Xu, Catherine Theriault,Albena Davidova,Vanessa Soubeyre, Gaetan Poulen,Nicolas Lonjon, Florence Vachiery-Lahaye,Luc Bauchet,Philipa Levesque-Damphousse,
Proceedings of the National Academy of Sciences of the United States of Americano. 27 (2024): e2403777121-e2403777121
Alice Gilbert, Lise Rabillier,Reza Sharif-Naeini,Lois Miraucourt,Miltiadis Georgiopoulos,Ines Colmegna,Jean Ouellet,Radhouane Dallel,Cédric Peirs
Osteoarthritis and Cartilageno. 6 (2024): 836
Frontiers in pain research (Lausanne, Switzerland) (2023): 1150749
PAIN REPORTSno. 5 (2023): e1090-e1090
Maham Zain, Laura Bennett,Hantao Zhang, Quinn Pauli, Juliet Arsenault,Shajenth Premachandran, Jenny Cheung,Christine Pham, Lexi Wowk, Sékou-Oumar Kaba,Samuel Fung,Irene Lecker,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Stephanie Mouchbahani-Constance, Camille Lagard, Justine Schweizer, Isabelle Labonté,Miltiadis Georgiopoulos,Colombe Otis,Manon St-Louis,Eric Troncy,Philippe Sarret,Alfredo Ribeiro-Da-Silva,Jean A. Ouellet,Philippe Séguéla,
Neurobiology of Pain (2023): 100120
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Author Statistics
#Papers: 58
#Citation: 2704
H-Index: 23
G-Index: 45
Sociability: 6
Diversity: 3
Activity: 63
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