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个人简介
Starting with my PhD on untargeted metabolomics I have been involved with early and novel applications of high resolution Orbitrap technology with a strong focus on both LC/MS and bioinformatics. During my post-doctoral fellowship with Prof. Matthias Mann at the Max Planck Institute of Biochemistry my investigations into LC/MS data analysis have continued by joining the MaxQuant development team (a popular shotgun proteomics data analysis software package). Furthermore, I have shifted focus to the optimization of data acquisition. For this, software and hardware solutions have been developed that improve chromatography, perform quality assessments and provide early warning in case of problems. Additionally, they improve control of the mass spectrometer in real-time enabling novel data acquisition strategies. A striking example of this has been the optimization of crosslinking experiments utilizing gas-phase cleavable crosslinkers. In 2015 I joined Prof. Albert Heck at the Utrecht University as an assistant professor to start up my own group focusing on Protein Complex Topology and Dynamics.
My work history spans many aspects providing me with strong skills in mass spectrometry data analysis (mzMatch, MaxQuant, Andromeda), statistical analysis (recently culminating in a Science publication Meissner et al; 2013), and LC/MS data acquisition (SprayQc, MaxQuant Real-time). The developed techniques have been used in the investigations into various facets of immune response and inflammation, including: metabolic changes involved in parasite drug resistance, metabolomics of surface barrier protection in s. coelicolor, innate immune cell protein secretion, adaptive immunity by elucidating the CRISPR type III protein complex, and inflammation onset and repair.
研究兴趣
论文共 94 篇作者统计合作学者相似作者
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Journal of thrombosis and haemostasis : JTHno. 5 (2024): 1336-1346
Jurre A Steens,Jack P K Bravo,Carl Raymund P Salazar,Caglar Yildiz, Afonso M Amieiro,Stephan Köstlbacher,Stijn H P Prinsen, Ane S Andres,Constantinos Patinios, Andreas Bardis,Arjan Barendregt,Richard A Scheltema,
Science (New York, N.Y.)no. 6682 (2024): 512-519
Journal of Thrombosis and Haemostasis (2024): 100326-100326
Laurens De Sadeleer,Yuexin Chen, Christoph Jentzsch, Zhenda Wang, Niyeti Qazi,Niklas Lang,Pascal Albanese,Andris Jankevics,Fabian Theis,Richard Scheltema,Wim Wuyts,Janine Gote-Schniering,
EUROPEAN RESPIRATORY JOURNAL (2023)
Yuexin Chen,Janine Gote-Schniering, Michaela Mueller,Pascal Albanese,Andris Jankevics, R. Christoph Jentzsch,Aleksandra Tata,Meshal Ansari,Laurens De Sadeleer,Lin Yang,Lukas Heumos,Ahmed Agami,
EUROPEAN RESPIRATORY JOURNAL (2023)
Max Gemmer,Marten L. Chaillet, van Loenhout J,Rodrigo Cuevas Arenas, Dimitrios Vismpas,Mariska Gröllers-Mulderij,Fujiet Koh,Pascal Albanese,Richard A. Scheltema, Howes SC,Abhay Kotecha,Juliette Fédry,
EMPIAR dataset (2023)
Molecular & Cellular Proteomicsno. 5 (2023): 100759-100759
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