Rashesh Sanghvi - Wellcome Sanger Institute

基本信息

Career Trajectory

Bio

Rashesh Sanghvi currently works at Wellcome Sanger Institue (Cancer, Ageing and Somatic Mutation). Rashesh is a senior bioinformatician in the Rahbari group focusing on somatic mutations evolution in normal tissues, specifically focusing on Germ cell tissue. His interest lies in studying mutations acquired with age leading to predisposition to cancer and other mendelian diseases.

Research Interests

Papers共 29 篇Author StatisticsCo-AuthorSimilar Experts

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The Genomic and Clinical Consequences of Replacing Procarbazine with Dacarbazine in Escalated BEACOPP for Hodgkin Lymphoma: a Retrospective, Observational Study

Anna Santarsieri,Emily Mitchell,My H. Pham,Rashesh Sanghvi, Janina Jablonski, Henry Lee-Six,Katherine Sturgess,Pauline Brice,Tobias F. Menne,Wendy Osborne,Thomas Creasey,Kirit M. Ardeshna,Joanna Baxter,Sarah Behan,Kaljit Bhuller, Stephen Booth,Nikesh Chavda,Graham P. Collins,Dominic J. Culligan,Kate Cwynarski, Andrew Davies, Abigail Downing,David Dutton,Michelle Furtado,Eve Gallop-Evans,Andrew Hodson,David Hopkins,Hannah Hsu,Sunil Iyengar,Stephen G. Jones,Mamatha Karanth,Kim M. Linton,Oliver C. Lomas,Nicolas Martinez-Calle,Abhinav Mathur,Pamela Mckay,Sateesh K. Nagumantry,Elizabeth H. Phillips,Neil Phillips,John F. Rudge,Nimish K. Shah,Gwyneth Stafford,Alex Sternberg,Rachel Trickey,Benjamin J. Uttenthal, Natasha Wetherall, Xiao-Yin Zhang, K. Mcmillan,Nicholas Coleman,Michael R. Stratton,Elisa Laurenti,Peter Borchmann,Sven Borchmann,Peter J. Campbell,Raheleh Rahbari,George Follows

LANCET ONCOLOGYno. 1 (2025): 98-109

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Cancer-independent Somatic Mutation of the Wild-Type NF1 Allele in Normal Tissues in Neurofibromatosis Type 1

Nature geneticsno. 3 (2025): 515-521

Cited0Views0WOSNATUREBibtex

The Impact of Ancestral, Environmental and Genetic Influences on Germline De Novo Mutation Rates and Spectra

O Isaac Garcia-Salinas,Seongwon Hwang, Qin,Rashesh Sanghvi, Daniel S Malawsky, Joanna Kaplanis,Matthew D C Neville,Felix R Day,Raheleh Rahbari,Aylwyn Scally,Hilary C Martin

Nature communicationsno. 1 (2025): 4527-4527

Cited1Views0WOSBibtex

Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

Matthew DC Neville,Andrew RJ Lawson,Rashesh Sanghvi,Federico Abascal,My H Pham,Alex Cagan, Pantelis A Nicola, Tetyana Bayzetinova,Adrian Baez-Ortega,Kirsty Roberts,Stefanie V Lensing,Sara Widaa,Raul E Alcantara,Maria Paz Garcia, Sam Wadge,Michael R Stratton,Peter J Campbell,Kerrin Small,Inigo Martincorena,Matthew E Hurles,Raheleh Rahbari

crossref（2024）

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The long-term effects of chemotherapy on normal blood cells

Emily Mitchell, Mimy H. Pham,Anna Clay,Rashesh Sanghvi, Sandra Pietsch,Joanne I. Hsu,Hyunchul Jung,Aditi Vedi,Sarah Moody,Jingwei Wang, Daniel Leonganmornlert,Michael Spencer Chapman,Nicholas Williams, Ellie Dunstone,Anna Santarsieri,Alex Cagan,Heather E. Machado,Joanna Baxter,George Follows,Daniel J. Hodson,Ultan McDermott, Gary J. Docherty,Inigo Martincorena,Laura Humphreys,Krishnaa Mahbubani,Kourosh Saeb Parsy,Koichi Takahashi,Margaret A. Goodell,David Kent,Elisa Laurenti,Peter J. Campbell,Raheleh Rahbari, Jyoti Nanglia,Michael R. Stratton

biorxiv（2024）

Cited2Views0Bibtex

Insights into Non-Crossover Recombination from Long-Read Sperm Sequencing

Regev Schweiger, Sangjin Lee,Chenxi Zhou,Tsun-Po Yang, Katie Smith,Stacy Li,Rashesh Sanghvi,Matthew Neville,Emily Mitchell,Ayrun Nessa,Sam Wadge,Kerrin S Small,Peter J Campbell,Peter H Sudmant,Raheleh Rahbari,Richard Durbin

bioRxiv the preprint server for biology (2024)

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Procarbazine-induced Genomic Toxicity in Hodgkin Lymphoma Survivors

Anna Santarsieri,Emily Mitchell,My H Pham,Rashesh Sanghvi, Janina Jablonski,Henry Lee-Six,Katherine Sturgess,Pauline Brice,Tobias F Menne,Wendy Osborne,Thomas Creasey,Kirit M Ardeshna,Joanna Baxter,Sarah Behan,Kaljit Bhuller,Stephen Booth, Nikesh D Chavda,Graham P Collins,Dominic J Culligan,Kate Cwynarski,Andrew Davies, Abigail Downing,David Dutton,Michelle Furtado,Eve Gallop-Evans,Andrew Hodson,David Hopkins,Hannah Hsu,Sunil Iyengar,Stephen G Jones,Mamatha Karanth,Kim M Linton,Oliver C Lomas,Nicolas Martinez-Calle,Abhinav Mathur,Pam McKay,Sateesh K Nagumantry,Elizabeth H Phillips,Neil Phillips,John F Rudge,Nimish K Shah,Gwyneth Stafford,Alex Sternberg,Rachel Trickey,Benjamin J Uttenthal, Natasha Wetherall,Xiao-Yin Zhang,Andrew McMillan,Nicholas Coleman,Michael R Stratton,Elisa Laurenti,Peter Borchmann,Sven Borchmann,Peter J Campbell,Raheleh Rahbari,George A Follows

medrxiv（2024）

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A Naturally Occurring Variant of MBD4 Causes Maternal Germline Hypermutation in Primates

Alexandra M. Stendahl,Rashesh Sanghvi,Samuel Peterson,Karina Ray,Ana C. Lima,Raheleh Rahbari,Donald F. Conrad

GENOME RESEARCH（2023）

Cited4Views0WOSBibtex

Replacing procarbazine with dacarbazine in escalated BEACOPP protects stem cells from excessive somatic mutational damage

Anna Santarsieri,Emily Mitchell,Rashesh Sanghvi,Henry Lee-Six,Michael Stratton,Raheleh Rahbari,Elisa Laurenti,Peter J. Campbell,George A. Follows

BRITISH JOURNAL OF HAEMATOLOGY (2023): 14-14

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