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Dr. Ryan's lab studies the regulatory control of oncogene expression in B-cell lymphomas and leukemias, a clinically and biologically diverse group of human cancers derived from a single cellular lineage. Genetic driver events in B-cell lymphoma include genomic rearrangements that activate oncogenes such as MYC, BCL2, BCL6, and CCND1 via juxtaposition to powerful distal regulatory elements (enhancers) derived from heterologous genomic sites, such as the immunoglobulin loci. Detection of these rearrangement events, as well as overexpression of oncogene protein products, plays a central role in the classification and clinical management of B-cell cancers, but mechanisms that lead to oncogene overexpression in the absence of genomic rearrangement remain poorly understood.
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论文共 58 篇作者统计合作学者相似作者
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Human pathology (2023): 34-43
Ashwin R Iyer,Aishwarya Gurumurthy,Rohan Kodgule, Athalee R Aguilar,Travis Saari, Abdullah Ramzan,Dylan Rausch,Juhi Gupta,Cody N Hall,John S Runge,Matthew Weiss,Mahshid Rahmat,
bioRxiv : the preprint server for biology (2023)
Rohan Kodgule,Joshua W Goldman,Alexander C Monovich, Travis Saari, Athalee R Aguilar,Cody N Hall, Niharika Rajesh, Juhi Gupta, Shih-Chun A Chu, Li Ye,Aishwarya Gurumurthy,Ashwin Iyer,
Blood cancer discoveryno. 1 (2023): 34-53
Mark Y Chiang,Qing Wang, Carea Mullin,Elizabeth Choe,Nicole Dean,Fatema Akter,Siyi Chen,Ashley Melnick,Anna McCarter,Rohan Kodgule, Raghu Vannam, Christopher J. Ott,
Ashley Melnick,Anna McCarter, Shannon Liang,Nicole Dean,Elizabeth Choe,Nicholas Kunnath,Brian Magnuson, Karena Lin,Qing Wang,Surinder Kumar,David Lombard,Russell J.H. Ryan,
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