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个人简介
My research interests have been centered on the study of cellular signalling, with special focus on intracellular calcium homeostasis. I developed an innovative methodology, organelle targeting of recombinant luminescent (aequorin, luciferase) and fluorescent (GFP) proteins, that allowed novel insight in the fields of calcium signalling, cellular metabolism and organelle morphology. New concepts have been acquired, which include the participation of mitochondria in cellular Ca2+ homeostasis and their role in translating calcium signals in effects as diverse as stimulation of metabolism and induction of cell death, the occurrence of tight signalling interactions between the endoplasmic reticulum and mitochondria, the identification of the Golgi apparatus as an agonist-sensitive Ca2+ store, and the major Ca2+ rises occurring under the plasma membrane upon cell stimulation, to cite a few. In 2011, I identified the mitochondrial calcium uniporter (MCU), the only fundamental component of the cellular calcium signalling machinery yet to be discovered. This result has opened the molecular era of mitochondrial Ca2+ homeostasis, that combines molecular insight into the structure/function relationship of MCU and its regulators and the possibility of manipulating mitochondrial Ca2+ handling in cultured cells and animal models, with the goal of clarifying its role in the physiological regulation of tissues and in the pathogenesis of the most prevalent human diseases (neurodegenerative disorders, ischemic heart disease, cancer).
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Cell Death & Diseaseno. 1 (2024)
SCIENTIFIC REPORTSno. 1 (2024): 8469-8469
Giulia Di Marco,Gaia Gherardi,Agnese De Mario, Ilaria Piazza,Martina Baraldo,Andrea Mattarei,Bert Blaauw,Rosario Rizzuto,Diego De Stefani,Cristina Mammucari
Journal of Hepatology (2023): S322-S322
Paola Mason,Rosario Rizzuto,Luca Iannelli, Flavio Baccaglini, Valerio Rizzolo, Andrea Baraldo,Barbara Melloni, Francesca Maffione, Camilla Pezzoli, Maria Laura Chiozza, Giampietro Rupolo, Marco Biasioli,
Vaccinesno. 5 (2023)
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biorxiv(2023)
Digestive and Liver Disease (2023): S11-S11
Donato D'Angelo,Rosario Rizzuto
Biomoleculesno. 9 (2023)
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