Prof. Misra's research interests are in high energy astrophysics which includes accretion disk theory, study of spectral and timing properties of X-ray binaries, ultra-luminous X-ray sources, large-scale radio/X-ray jets of AGN and, lately, gamma-ray bursts. His research involves theoretical modeling as well as X-ray data analysis and interpretation. Prof. Misra is also interested in cross-disciplinary studies like non-linear dynamics of astrophysical systems, non-linear time series analysis and statistical classificiation schemes of astrophysical sources.