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The Marmorstein laboratory studies the molecular mechanisms of (1) protein post- and co-translational protein acetylation and acetyl-CoA metabolism, (2) gene expression and epigenetic regulation, and (3) MAPK signaling. The laboratory uses a broad range of biochemical, biophysical and structural research tools (X-ray crystallography and cryo-EM) to determine macromolecular structure and mechanism of action, with a particular focus on macromolecules that are aberrantly regulated in age-associated diseases such as cancer, and metabolic and neurodegenerative disorders. The laboratory also uses high-throughput small molecule screening and structure-based design strategies to develop protein-specific small-molecule probes to interrogate protein function and for preclinical studies. Specific areas of focus are described below:
The Marmorstein laboratory studies the molecular mechanisms of (1) protein post- and co-translational protein acetylation and acetyl-CoA metabolism, (2) gene expression and epigenetic regulation, and (3) MAPK signaling. The laboratory uses a broad range of biochemical, biophysical and structural research tools (X-ray crystallography and cryo-EM) to determine macromolecular structure and mechanism of action, with a particular focus on macromolecules that are aberrantly regulated in age-associated diseases such as cancer, and metabolic and neurodegenerative disorders. The laboratory also uses high-throughput small molecule screening and structure-based design strategies to develop protein-specific small-molecule probes to interrogate protein function and for preclinical studies. Specific areas of focus are described below:
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论文共 317 篇作者统计合作学者相似作者
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Romain Riscal,Sarah M. Gardner,Nathan J. Coffey, Madeleine Carens,Clementina Mesaros,Jimmy P. Xu, Yizheng Xue, Leah Davis, Sara Demczyszyn,Austin Vogt, Adam Olia,Jennifer M. Finan,
crossref(2024)
Julianna G. Supplee,Hayley C. Affronti, Richard Duan,Rebekah C. Brooks,Zachary E. Stine,Phuong T.T. Nguyen, Laura V. Pinheiro,Michael C. Noji, Jack M. Drummond, Kevin Huang,Kollin Schultz,Chi V. Dang,
Journal of Biological Chemistryno. 7 (2024): 107418-107418
Xue Hao,Bo Zhao,Martina Towers,Liping Liao,Edgar Luzete Monteiro, Xin Xu, Christina Freeman, Hongzhuang Peng,Hsin-Yao Tang,Aaron Havas,Andrew V. Kossenkov,Shelley L. Berger,
Nature Agingno. 2 (2024): 1-13
Romain Riscal,Sarah M. Gardner,Nathan J. Coffey, Madeleine Carens,Clementina Mesaros,Jimmy P. Xu, Yizheng Xue, Leah Davis, Sara Demczyszyn,Austin Vogt, Adam Olia,Jennifer M. Finan,
crossref(2024)
Romain Riscal,Sarah M. Gardner,Nathan J. Coffey, Madeleine Carens,Clementina Mesaros,Jimmy P. Xu, Yizheng Xue, Leah Davis, Sara Demczyszyn,Austin Vogt, Adam Olia,Jennifer M. Finan,
crossref(2024)
Romain Riscal,Sarah M. Gardner,Nathan J. Coffey, Madeleine Carens,Clementina Mesaros,Jimmy P. Xu, Yizheng Xue, Leah Davis, Sara Demczyszyn,Austin Vogt, Adam Olia,Jennifer M. Finan,
crossref(2024)
Romain Riscal,Sarah M. Gardner,Nathan J. Coffey, Madeleine Carens,Clementina Mesaros,Jimmy P. Xu, Yizheng Xue, Leah Davis, Sara Demczyszyn,Austin Vogt, Adam Olia,Jennifer M. Finan,
crossref(2024)
Romain Riscal,Sarah M. Gardner,Nathan J. Coffey, Madeleine Carens,Clementina Mesaros,Jimmy P. Xu, Yizheng Xue, Leah Davis, Sara Demczyszyn,Austin Vogt, Adam Olia,Jennifer M. Finan,
crossref(2024)
Mingyang Zhou,Supuni Thalalla Gamage, Khoa A Tran,David Bartee,Xuepeng Wei, Boyu Yin,Shelley Berger,Jordan L Meier,Ronen Marmorstein
bioRxiv : the preprint server for biology (2024)
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