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个人简介
Professor Caprioli is interested in the use of mass spectrometry for the analysis of compounds in biological systems. Current work includes the use of electrospray and laser desorption ionization methods with biological tissues and samples. Applications have focused on the development of this instrumentation and associated methodologies to achieve ultra-high sensitivity detection of endogenous compounds (e.g., neuropeptides) in live animal systems. Recent work involves the development of Imaging Mass Spectrometry, a technique whereby molecular images of peptides, proteins, drugs and other compounds are localized in tissue sections with molecular weight specificity. This method involves molecular mapping of animal tissue through the production of ion images obtained from the analysis of mammalian tissue. Applications to specific research areas involve questions about certain spatial distributions of molecules within specific tissues, e.g., mapping proteins in cancer tissue. Specific applications include human glioblastomas, breast cancer, colorectal cancer and lung cancer.
研究兴趣
论文共 822 篇作者统计合作学者相似作者
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PloS oneno. 5 (2024): e0304709-e0304709
Zachary J Sasiene, Erick S LeBrun, Nileena Velappan, Austin R Anderson,Nathan H Patterson,Martin Dufresne,Melissa A Farrow,Jeremy L Norris,Richard M Caprioli,Phillip M Mach,Ethan M McBride,Trevor G Glaros
The Analystno. 13 (2024): 3564-3574
Katerina V Djambazova,Katherine N Gibson-Corley, Jeffrey A Freiberg,Richard M Caprioli,Eric P Skaar, Jeffrey M Spraggins
Journal of the American Society for Mass Spectrometry (2024)
ANALYTICAL CHEMISTRYno. 13 (2024): 5065-5070
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