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职业迁徙
个人简介
I am a geneticist and a biochemist who has a long history of applying insights from fundamental discoveries to understanding the cause of cancer. My research is directed at understanding the pathways that prevent the accumulation of mutations and genome rearrangements, how defects in these pathways drive the development of cancer and developing therapies that target defects in these pathways in cancer. Our fundamental discoveries about DNA mismatch repair and the pathways that prevent genome instability have proved to be central to understanding the genetics of cancer susceptibility. Our most recent efforts include studies of human genome instability suppressing genes that are defective in many cancers and studies of small molecule inhibitors that are potential anti-cancer agents for cancers with increased genome instability.
研究兴趣
论文共 362 篇作者统计合作学者相似作者
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BioEssays : news and reviews in molecular, cellular and developmental biologyno. 9 (2023)
DNA repair (2022): 103405-103405
Felipe A. Calil,Bin-Zhong Li,Kendall A. Torres, Katarina Nguyen,Nikki Bowen, Christopher D. Putnam,Richard D. Kolodner
Research Square (Research Square) (2021)
Elaine Guo,Yuki Ishii,James Mueller,Anjana Srivatsan, Timothy Gahman, Christopher D Putnam,Jean Y J Wang,Richard D Kolodner
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