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Our group is interested in the mechanisms of membrane fusion, with the main emphasis on regulated exocytosis in neurons. Intracellular membrane fusion events are mediated by a set of conserved membrane proteins, termed SNAREs. For fusion to occur, complementary sets of SNAREs need to be present on both of the fusing membranes, which then assemble in a zipper-like fashion to initiate membrane merger. The neuronal SNAREs are among the best characterized. They are the targets of the toxins responsible for botulism and tetanus, and they are regulated by several addtional proteins including synaptotagmin, the calcium sensor for neurotransmitter release. To understand how these proteins mediate fusion, we study their properties in vitro with biochemical and biophysical approaches using native and artificial membranes.
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Proceedings of the National Academy of Sciences of the United States of Americano. 2 (2024): e2309161121-e2309161121
Nature Communicationsno. 1 (2024): 1-14
Nature Reviews Molecular Cell Biologyno. 2 (2024): 101-118
Jette Alfken,Charlotte Neuhaus, András Major, Alyona Taskina,Christian Hoffmann,Marcelo Ganzella, Arsen Petrovic,David Zwicker,Rubén Fernández-Busnadiego,Reinhard Jahn, Dragomir Milovanovic,Tim Salditt
The European physical journal. E, Soft matterno. 1 (2024): 8-8
Molecular & Cellular Proteomicsno. 2 (2024): 100704-100704
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