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个人简介
Research Focus
Proper control of metabolism is required for essentially every biological process. Altered metabolism at the cellular level contributes to many diseases, including inborn errors of metabolism (the result of inherited genetic defects in metabolic enzymes that lead to chemical imbalances in children) and cancer. Our laboratory seeks to characterize these metabolic disorders, understand how they compromise tissue function, develop methods to monitor metabolism in vivo, and design therapies to restore normal metabolism and improve health.
In cancer, we study how oncogenic control of metabolism supports tumor initiation and progression. In inborn errors of metabolism, we use metabolomics and genomics to identify new disease genes and deepen our understanding of metabolism’s role in human health. Our research is closely integrated with clinical activities in medical genetics, oncology, and radiology, providing seamless opportunities to examine the relevance of our findings in patients.
Proper control of metabolism is required for essentially every biological process. Altered metabolism at the cellular level contributes to many diseases, including inborn errors of metabolism (the result of inherited genetic defects in metabolic enzymes that lead to chemical imbalances in children) and cancer. Our laboratory seeks to characterize these metabolic disorders, understand how they compromise tissue function, develop methods to monitor metabolism in vivo, and design therapies to restore normal metabolism and improve health.
In cancer, we study how oncogenic control of metabolism supports tumor initiation and progression. In inborn errors of metabolism, we use metabolomics and genomics to identify new disease genes and deepen our understanding of metabolism’s role in human health. Our research is closely integrated with clinical activities in medical genetics, oncology, and radiology, providing seamless opportunities to examine the relevance of our findings in patients.
研究兴趣
论文共 481 篇作者统计合作学者相似作者
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Molecular Genetics and Metabolismno. 4 (2024): 108282
Walter W. Chen,Tony A. Rodrigues,Daniel Wendscheck,Ana G. Pedrosa,Chendong Yang,Tânia Francisco, Till Möcklinghoff, Alexandros Zografakis, Bernardo Nunes-Silva, Reut Ester Avraham, Ana R. Silva,Maria J. Ferreira,
biorxiv(2024)
Divya Bezwada, Luigi Perelli, Nicholas P Lesner, Ling Cai, Bailey Brooks, Zheng Wu, Hieu S Vu, Varun Sondhi, Daniel L Cassidy, Stacy Kasitinon, Sherwin Kelekar, Feng Cai,
Naturepp.1-9, (2024)
Dylan Calhoon, Lingjie Sang,Divya Bezwada, Nathaniel Kim,Amrita Basu, Sheng-Chieh Hsu, Anastasia Pimentel,Bailey Brooks,Konnor La, Ana Paulina Serrano, Daniel L Cassidy,Ling Cai,
biorxiv(2024)
Science (New York, N.Y.)no. 6701 (2024): eadj4301-eadj4301
biorxiv(2024)
Juho Aaltio,Liliya Euro, Olli Tynninen,Hieu S. Vu,Min Ni,Ralph J. Deberardinis, Anu Suomalainen,Pirjo Isohanni
Neuromuscular Disorders (2024)
SCIENCE ADVANCESno. 13 (2024): eado7808-eado7808
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作者统计
#Papers: 466
#Citation: 62243
H-Index: 98
G-Index: 249
Sociability: 8
Diversity: 0
Activity: 5
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