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The current studies examine the molecular mechanisms linking the drivers of mitophagy and autophagy with the mechanisms governing the symmetry of cell division and stem cell expansion. It is proposed that the symmetry of cell division is a determinant of stem cell expansion and that it is the cancer stem cells that give rise to therapy resistance. We are examining the role of key pathways in this biological interface using inducible deletion mice for cyclins, NFKB and Akt1.
We examine cell fate determination and its role in tumorigenesis using Dachshund transgenics. Dachshund plays a key role in specifying organismal development and the generation of tissues including the brain, yet appears to play a key role in tumorigenesis.
The role of cyclins in several types of tumors are being assessed assessing the non canonical functions. The non canonical functions contribute to miRNA maturation and expression, stem cell function and heterotypic signals.
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Zhiping Li,Xuanmao Jiao, Taimoor Khan, Danni Li,Shan Zha,Lai Yee Phoon,Li Lan,A. Gordon Robertson,Anthony W. Ashton, Kenneth A. Iczkowski, Alexander D. Borowsky,Alan Ashworth,
Cancer Researchno. 6_Supplement (2024): 5581-5581
Cancer Researchno. 6_Supplement (2024): 3582-3582
Xuanmao Jiao,Anthony W. Ashton,Zhiping Li, Ritika Harish, Danni Li,Gordon Robertson,Duanwen Shen,Xiaoming Ju,Ke Chen, Wei Zhang, Samuel Archilefu, Kenneth A. Iczkowski,
Cancer Researchno. 6_Supplement (2024): 1634-1634
Xuanmao Jiao,Gabriele Di Sante,Mathew C. Casimiro,Agnes Tantos,Anthony W. Ashton,Zhiping Li, Yen Quach, Dharmendra Bhargava,Agnese Di Rocco, Claudia Pupo,Marco Crosariol,Tamas Lazar,
Anthony W. Ashton, Harpreet K. Dhanjal, Benjamin Rossner, Huma Mahmood, Vivek Patel, Mohammad Nadim, Manpreet Lota,Farhan Shahid, Zhiping Li,David Joyce, Matyas Pajkos,Zsuzsanna Dosztanyi,
Xuanmao Jiao,Xin Sun,Zhiping Li,Xiaoming Ju, Danni Li, Ritika Harish,Gordon Robertson,Anthony W. Ashton,Richard G. Pestell
Cancer Researchno. 6_Supplement (2024): 261-261
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