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个人简介
I graduated in Biochemistry from Imperial College in 2000 before starting my research career with a PhD under Richard Perham FRS at the University of Cambridge. In close collaboration with Ben Luisi I investigated the assembly and catalytic mechanisms of multienzyme complexes by biochemical reconstitution, X-ray crystallography. After graduating in 2004, I used a two year postdoctoral position with Ben Luisi to solve several other structures and discover a novel free radical by EPR with Christopher Kay. In 2006 I used a Royal Commission for the Exhibition of 1851 Research Fellowship to switch fields entirely and join Seth Grant’s group at the Wellcome Trust Sanger Institute. In Seth's group I used mouse genetics and human genetics to study glutamatergic synapses. To continue this work, I obtained a Sir Richard Wilson Junior Research Fellowship at Emmanuel College Cambridge and generated a TAP-tagged GluN1 knockin mouse. I was also invited as a visiting scientist to the MRC LMB by Nigel Unwin FRS to learn cryo-electron microscopy. In 2013 I was recruited by Michel Goedert FRS (Head of the Division of Neurobiology, MRC-LMB) to work as a postdoctoral scientist combining mouse genetics and cryo-electron microscopy to investigate synapses and neurodegeneration. In 2018, I was recruited by the University of Leeds as a University Academic Fellow in Structural Neuroscience to form an independent research group. My group are using mouse genetics and cryo-electron tomography to investigate the in situ 3D molecular structure of synapses and Alzheimer’s disease-associated pathology.
研究兴趣
论文共 31 篇作者统计合作学者相似作者
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Conny Leistner, M. K. Wilkinson, Ailidh Burgess,Megan Lovatt, S Goodbody,Yong Xu,Susan A. Deuchars,Sheena E. Radford,Neil A. Ranson,René Frank
EMPIAR dataset (2023)
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Mark R. Gilbert, Nayab Fatima,Joshua Jenkins, Thomas D. O’Sullivan,Andreas Schertel, Y. Halfon,Tjado H. J. Morrema, Mirjam Geibel,Sheena E. Radford, Jeroen J. M. Hoozemans,René Frank
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Conny Leistner, M. K. Wilkinson, Ailidh Burgess,Megan Lovatt, S Goodbody,Yong Xu, Susan A. Deuchars,Sheena E. Radford,Neil A. Ranson,René Frank
EMPIAR dataset (2023)
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Nature Communicationsno. 1 (2023): 1-12
Conny Leistner, M. K. Wilkinson, Ailidh Burgess,Megan Lovatt, S Goodbody,Yong Xu,Susan A. Deuchars,Sheena E. Radford,Neil A. Ranson,René Frank
EMPIAR dataset (2023)
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Natalie Al-Otaibi,Pieter Baatsen,David Bhella, Rosaria Brescia,Per Bullough,Bertram Daum, Reinier de Bruin,Rene Frank,Werner Kuhlbrandt,Carmen Lopez-Iglesias,Mathew McLaren,Rebbekah Menday,
FARADAY DISCUSSIONSno. 0 (2022): 142-151
Saskia E. Bakker,Julien Bergeron,Alok Bharadwaj,David Bhella,Per Bullough, Pak-Lee Chau,Rene A. W. Frank,Arjen J. Jakobi,Agnel Praveen Joseph,Werner Kuhlbrandt, Indrajit Lahiri,Rebbekah Menday,
FARADAY DISCUSSIONS (2022): 229-242
Saskia E Bakker,David Bhella, Rosaria Brescia,Per Bullough,Daniel K Clare,Bertram Daum,René A W Frank,Vicki A M Gold, Isobel Jackson Hirst,Werner Kühlbrandt,Penghan Lu,Mathew McLaren,
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