基本信息
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Bio
Rosaura Esteve-Puig, Ph.D., is a molecular biologist, pursuing an understanding of tumor biology and molecular mechanisms of drug resistance to reveal novel clinical therapies since 2005. Currently, Dr. Esteve-Puig is a Principal Scientist-Oncology Translational Leader at MAJ3 Health based in Barcelona, Spain.
Expert in cancer cell and molecular biology, genetics, epigenetics, epitranscriptomics, and cell signaling.
Publication record is highlighted by her first and second-author articles in top peer-reviewed journals such as Blood and Nature Communications. Dr. Esteve-Puig is co-author of 14 scientific articles, in which 5 of them as the first author, were remarkably started from the drawing board, and 4 of them as the second author.
The most relevant contributions as the first and second author are the discoveries of (1) RNA-modifying enzyme ALKBH3 as a prognostic biomarker in hematological malignancies (Esteve-Puig et al., Blood, 2021) ; (2) BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy (McGrail et al., Nature Communications, 2022) ; (3) lincRNA MIRAT, a cytoplasmic long noncoding RNA (lncRNA) and its emerging role in modulating oncogenic signaling pathways, a future promising strategy for combating one of the multiple drug resistance mechanisms in melanoma (Esteve-Puig et al., Scientific Reports, 2018); (4) the missing pieces in the UV-induced DNA damage response pathway (Esteve-Puig et al., PloS Genetics, 2014) ; (5) a new mechanism for the modulation of the ERK pathway signaling by protein methylation; (6) LKB1 kinase protein as the link between RAF/MEK/ERK and LKB1/AMPK/mTOR signaling pathways, suggesting a novel metabolic therapy for cancer treatment (Esteve-Puig et al., PloS One, 2009) ; and (7) identification and characterization of new kinase fusions in spitzoid melanomas (Wiesner et al., Nature Communications, 2014).
Research Interests
Papers共 22 篇Author StatisticsCo-AuthorSimilar Experts
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Beth Apsel Winger,Wilian A. Cortopassi,Diego Garrido Ruiz,Lucky Ding, Kibeom Jang, Ariel Leyte-Vidal,Na Zhang,Rosaura Esteve-Puig, Matthew P. Jacobson,Neil P. Shah
crossref(2023)
Beth Apsel Winger,Wilian A. Cortopassi,Diego Garrido Ruiz,Lucky Ding, Kibeom Jang, Ariel Leyte-Vidal,Na Zhang,Rosaura Esteve-Puig,Matthew P. Jacobson,Neil P. Shah
crossref(2023)
Alain P Algazi,Rosaura Esteve-Puig,Adi Nosrati,Brian Hinds, Adele Hobbs-Muthukumar, Prachi Nandoskar,Susana Ortiz-Urda,Paul B Chapman,Adil Daud
Cancer Research (2017): 3493-3493
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