Research Focus
Proper control of metabolism is required for essentially every biological process. Altered metabolism at the cellular level contributes to many diseases, including inborn errors of metabolism (the result of inherited genetic defects in metabolic enzymes that lead to chemical imbalances in children) and cancer. Our laboratory seeks to characterize these metabolic disorders, understand how they compromise tissue function, develop methods to monitor metabolism in vivo, and design therapies to restore normal metabolism and improve health.

In cancer, we study how oncogenic control of metabolism supports tumor initiation and progression. In inborn errors of metabolism, we use metabolomics and genomics to identify new disease genes and deepen our understanding of metabolism’s role in human health. Our research is closely integrated with clinical activities in medical genetics, oncology, and radiology, providing seamless opportunities to examine the relevance of our findings in patients.