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个人简介
The Brekken laboratory is part of the Division of Surgical Oncology and located in the Hamon Center for Therapeutic Oncology Research on the 8th floor of the Simmons Biomedical Research Building (NB) on the North campus of UT Southwestern. The broad interest of the lab is to study the microenvironment of tumors with a particular emphasis on extracellular matrix (ECM) deposition and remodeling, regulation and manipulation of tumor angiogenesis, and the testing of novel therapy.
To study the tumor microenvironment we use models of pancreatic, breast and lung cancer. Pancreatic cancer is particularly well-suited for evaluation of ECM deposition and remodeling as it is a highly desmoplastic disease. Breast cancer is also well suited for these studies and has been used frequently by investigators to study cell trafficking and angiogenesis. Lung cancer is a strength of the Hamon Center and we have utilized these resources to study pathways associated with therapy resistance.
Research Interest
Angiogenesis & ECM signaling
Cancer Therapy
Immune therapy
Metastasis
Tumor Microenvironment
研究兴趣
论文共 480 篇作者统计合作学者相似作者
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Austin Nguyen, Chanda Bhandari, Micah Keown, Ashritha Malkoochi, Maxwell Quaye, Doha Mahmoud,Nimit Shah, Dina Alzhanova,Colin G Cameron, Jacopo Ferruzzi,Sherri A McFarland, Gal Shafirstein,
Molecular pharmaceuticsno. 7 (2024): 3296-3309
Krystal C. Johnson,Audrius Kilikevicius,Cristina Hofman,Jiaxin Hu,Yang Liu, Selina Aguilar, Jon Graswich,Yi Han,Tao Wang,Jill M. Westcott,Rolf A. Brekken,Lan Peng,
NUCLEIC ACIDS RESEARCHno. 4 (2024): 1930-1952
Mauricio Marquez-Palencia, Luis Reza Herrera,Pravat Kumar Parida,Suvranil Ghosh,Kangsan Kim, Nikitha M. Das,Paula I. Gonzalez-Ericsson,Melinda E. Sanders,Bret C. Mobley, Sebastian Diegeler,Todd A. Aguilera,Yan Peng,
CANCER RESEARCHno. 5 (2024): 675-687
David Hsiehchen,Muhammad S. Beg,Radhika Kainthla,Jay Lohrey,Syed M. Kazmi,Leticia Khosama,Mary Claire Maxwell, Heather Kline,Courtney Katz, Asim Hassan,Naoto Kubota, Ellen Siglinsky,
CANCER RESEARCHno. 2 (2024)
biorxiv(2024)
Mauricio Marquez-Palencia, Luis Reza Herrera,Pravat Kumar Parida,Suvranil Ghosh,Kangsan Kim, Nikitha M Das,Paula I Gonzalez-Ericsson,Melinda E Sanders,Bret C Mobley, Sebastian Diegeler,Todd A Aguilera,Yan Peng,
Cancer researchno. 5 (2024): 675-687
Yuqing Zhang, Amanda Kirane, Huocong Huang,Noah B. Sorrelle,Francis J. Burrows,Michael T. Dellinger,Rolf A. Brekken
crossref(2023)
CANCER RESEARCHno. 7 (2023)
crossref(2023)
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