基本信息
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Bio
He was the first to establish a system that mediates stable suppression of gene expression through RNA interference (Brummelkamp et al., 2002 Science; and Brummelkamp et al., 2002 Cancer Cell), and used it for large-scale functional RNAi screens (Kolfschoten et al., 2005 Cell).
Next, he developed large-scale microRNA screens (Voorhoeve et al., 2006 Cell), genetic screens for key RNA-binding in microRNA biology and alternative polyadenylation of mRNAs (Kedde et al., 2007 Cell; and Jenal et al., 2012 Cell), genetic tools to measure amino acid shortages and linking transcription to mRNA translation via RNA modifications (Loayza-Puch et al., 2016 Nature; and Slobodin et al., 2017 Cell, respectively), and lastly functional genetic screens for regulatory DNA elements (Korkmaz et al., 2016 Nature Biotechnology). Altogether, these significant achievements constitute a proven strong track record of developing novel genetic tools for identifying key players linking gene regulation and disease.
Research Interests
Papers共 199 篇Author StatisticsCo-AuthorSimilar Experts
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Nicolaas J Boon, Rafaela A Oliveira,Pierré-René Körner, Adva Kochavi,Sander Mertens,Yuval Malka,Rhianne Voogd, Suzanne E M van der Horst,Maarten A Huismans,Lidwien P Smabers, Jonne M Draper,Lodewyk F A Wessels,
Science (New York, N.Y.)no. 6697 (2024): 785-792
Molecular Cellno. 10 (2024): 1904-1916.e7
Najla El-Hachem,Marine Leclercq, Miguel Susaeta Ruiz, Raphael Vanleyssem,Kateryna Shostak,Pierre-René Körner, Coralie Capron, Lorena Martin-Morales,Patrick Roncarati,Arnaud Lavergne,Arnaud Blomme,Silvia Turchetto,
Nature cell biologyno. 7 (2024): 1154-1164
Oncogeneno. 27 (2024): 2053-2062
crossref(2023)
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Author Statistics
#Papers: 197
#Citation: 29478
H-Index: 65
G-Index: 148
Sociability: 7
Diversity: 4
Activity: 145
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