Robert Bonomo
教授
Department of Pharmacology
School of Medicine, Case Western Reserve University;Cleveland Center for Membrane & Structural Biology, School of Medicine, Case Western Reserve University;Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University;Department of Medicine, School of Medicine, Case Western Reserve University
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基本信息
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个人简介
Among the major problems faced in medicine, resistance to antibiotics is regarded as a singular challenge. The primary focus of our laboratory is to understand the genetic and amino acid sequence determinants of the enzymes that inactivate ß-lactams, the ß-lactamases. Our current work is directed at solving three main problems:
how ß-lactamase inhibitors inactivate -lactamases;
how ß-lactamases hydrolyze advanced generation cephalosporins; and
how mutations impact upon ß-lactamase expression. We are also interested in how penicillin interacts with penicillin resistant PBPs and the molecular epidemiology of extended spectrum ß-lactamases (ESBLs).
研究兴趣
论文共 787 篇作者统计合作学者相似作者
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Elsa De la Cadena,María Fernanda Mojica, Laura J Rojas, Betsy E Castro,Juan Carlos García-Betancur,Steven H Marshall, Natalia Restrepo, Nancy Patricia Castro-Caro, Magalis Fonseca-Carrillo, Christian Pallares,Robert A Bonomo,María Virginia Villegas
Microbiology spectrumpp.e0410523-e0410523, (2024)
Alina Iovleva, Christi L McElheny, Erin L Fowler,Eric Cober,Erica S Herc,Cesar A Arias,Carol Hill, Keri Baum,Vance G Fowler,Henry F Chambers,Kerryl E Greenwood-Quaintance,Robin Patel,
Antimicrobial agents and chemotherapyno. 3 (2024): e0125823-e0125823
Antimicrobial agents and chemotherapypp.e0172023-e0172023, (2024)
Yuanyuan Jiao, Jun Yan,Dhruvitkumar S Sutaria, Peggy Lu,Michael Vicchiarelli,Zeferino Reyna, Juan Ruiz-Delgado,Elizabeth Burk, Eugene Moon,Nirav R Shah, Brad Spellberg,Robert A Bonomo,
Zachary L. Klamer,Cynthia M. June,Zdzislaw Wawrzak,Magdalena A. Taracila, Joshua A. Grey, Alyssa M. I. Benn, Christopher P. Russell,Robert A. Bonomo,Rachel A. Powers,David A. Leonard,Agnieszka Szarecka
Journal of Molecular Biologypp.168603-168603, (2024)
Yu Zhu,Jing Gu, Zhuoran Zhao, A W Edith Chan,Maria F Mojica,Andrea M Hujer,Robert A Bonomo,Shozeb Haider
Journal of chemical information and modelingno. 9 (2024): 3706-3717
CLINICAL INFECTIOUS DISEASES (2024)
Mary Nantongo,David C. Nguyen, Christopher R. Bethel,Magdalena A. Taracila, Qing Li,Khalid M. Dousa,Eunjeong Shin, Sebastian G. Kurz,Liem Nguyen,Barry N. Kreiswirth,W. Henry Boom,Mark S. Plummer,
ACS INFECTIOUS DISEASES (2024)
Zishuo Cheng,Mahesh Aitha,Caitlyn A Thomas, Aidan Sturgill, Mitch Fairweather, Amy Hu, Christopher R Bethel, Dann D Rivera,Patricia Dranchak,Pei W Thomas, Han Li, Qi Feng,
Journal of chemical information and modeling (2024)
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