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个人简介
His primary research interests center on ABC transporter-mediated drug disposition; structure, function and transport mechanism of ABC transporters; and mechanisms by which pregnancy affects drug/xenobiotic disposition including fetal exposure to drugs and xenobiotics through regulating drug disposition genes (drug metabolizing enzymes and transporters). Currently, his lab is interested in structure and function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2), one of the ATP-binding cassette (ABC) efflux transporters important for drug disposition. His lab is one of the first to demonstrate that BCRP in the placental barrier limits fetal exposure to drugs routinely used by pregnant women such as glyburide and nitrofurantoin using pregnant mouse models. His research interests have now extended to investigate how ABC efflux transporters in the placental barrier influence fetal exposure to cannabinoids which are being increasingly used by pregnant women as well as placental and fetal toxicity of cannabinoids. In addition, he is investigating the mechanisms by which pregnancy alters drug disposition through changing expression of drug disposition genes. In this regard, he found that the magnitude of change in drug disposition by pregnancy observed in humans could be replicated in mice, indicating that pregnant mice are appropriate animal models to study the mechanisms of changes in drug disposition by pregnancy which are difficult to study in humans due to ethical challenges. Using the mouse models, he has shown that the systemic exposure to various drugs is significantly altered by pregnancy through induction of drug-metabolizing enzymes such as Cyp3a and Ugt genes. Recently, he is expanding his research to examine how the gut microbiome affects drug disposition during pregnancy. Such studies are important for mechanistic understanding of how drugs can be safely and effectively used during pregnancy.
研究兴趣
论文共 101 篇作者统计合作学者相似作者
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Drug Metabolism and Pharmacokinetics (2024)
PHARMACEUTICSno. 2 (2024): 285
ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) (2024)
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
Drug metabolism and disposition: the biological fate of chemicalsno. 3 (2023): 269-275
Ana Correia-Branco,Ariel Mei, Sreehari Pillai, Nirmala Jayaraman, Radhika Sharma,Alison G Paquette,Naveen K Neradugomma, Ciara Benson,Nicholas W Chavkin,Qingcheng Mao,Mary C Wallingford
Vascular biology (Bristol, England)no. 1 (2023)
Drug Metabolism and Dispositionno. 3 (2022): 269-275
Medical Reviewno. 5 (2022): 501-511
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