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Research in Lu Lab aims to understand how distinct glial cell subtypes (oligodendrocytes, astrocytes and Schwann cells) in the central and peripheral nervous systems are generated, how they are regenerated after injury, and how their progenitors are transformed into cancerous cells under pathological conditions. We study the development and regeneration of glial progenitors using a variety of novel molecular, cellular and imaging technologies in combination with in vivo targeting and fate mapping approaches. A major focus of our lab research is to elucidate the transcriptional, posttranscriptional, epigenetic and signaling regulatory networks that govern glial progenitor fate specification, myelination and glioma formation. We have established a series of animal models for demyelinating neurodegenerative diseases such as multiple sclerosis, developmental neurological disorders such as CHARGE syndrome, MOWAT-WILSON syndrome and autisms, as well as brain tumor animal models and patients-derived xenograft models. Our research goal is to dissect the etiological mechanisms of these neurological diseases and develop effective therapies through promoting myelin repair, nerve regeneration or functional recovery in various neurological diseases, while blocking brain tumor initiation and progression.
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论文共 180 篇作者统计合作学者相似作者
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Antonia L Schmidt, Marco Kremp, Takaaki Aratake,Siying Cui,Yifeng Lin, Xiaowen Zhong,Q Richard Lu,Chengfu Zhang,Mengsheng Qiu, Tim Aberle,Michael Wegner
Gliano. 7 (2024): 1304-1318
Trends in Cell Biology (2024)
NEURO-ONCOLOGYno. 4 (2024): 735-748
Trends in cell biologyno. 7 (2024): 566-577
Trends in Cell Biology (2024)
NEUROSCIENTISTno. 3 (2023): 287-301
crossref(2023)
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