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覃文新,美国肝病研究学会Hepatology Communications杂志副主编。先后主持国家863计划、国家973计划、国家科技重大专项、国家自然科学基金重点国际合作课题等。在Lancet Oncology、Nature、Nature Communications、Gastroenterology、Hepatology等学术期刊发表论文120余篇。代表工作有,发现分泌蛋白DKK1与甲胎蛋白联合,可提高肝细胞癌的诊断率(Lancet Oncology 2012);揭示RCAN1.4是一个新型肝癌抑制分子,其下调可激活肝癌细胞CaN/NFAT信号通路,从而上调细胞因子IGF1和VEGFA的分泌,形成促癌微环境,促进肝癌恶性进展(Gastroenterology 2017);探索利用肿瘤细胞突变特异诱导肝癌细胞衰老,再定向清除衰老癌细胞而不杀伤正常细胞的分步式肝癌精准治疗策略(Nature 2019);发现仑伐替尼治疗无效的EGFR高表达肝癌患者,联合应用EGFR抑制剂治疗,可有效抑制肝癌进展(Nature 2021,封面论文)等。出版《肿瘤微环境》学术译著1部,参编《Primary Liver Cancer》英文著作1部。获美国专利2项、中国发明专利3项。
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Papers共 68 篇Author StatisticsCo-AuthorSimilar Experts
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crossref(2024)
Xupeng Yang, Chen Yang,Shu Zhang,Andrew X. Zhu,Haigang Geng,Rene Bernards,Wenxin Qin,Jia Fan,Cun Wang,Qiang Gao
crossref(2024)
Hui Wang,Shengxian Yuan, Quan Zheng, Sisi Zhang,Qianqian Zhang,Shuyi Ji,Wei Wang,Ying Cao,Yuchen Guo, Xupeng Yang,Haigang Geng,Fan Yang,
Gastroenterologyno. 6 (2024): 1130-1144.e8
Cancer Management and Research (2023): 351-362
Cancer Discoveryno. 7 (2023): 1276-1301
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2022): 59-64
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