Dr. Chen's laboratory has been focused on studying the molecular biology of oxidative stress, and she has 15 years of experience in utilizing genomic and proteomic technology to address basic science questions. She has trained 14 postdoctoral fellows, 11 Ph.D. and 4 M.S students. Ongoing research projects in her laboratory include 1) stress induced de novo protein synthesis for organ protection; 2) role of Nrf2 transcription factor in protection against cardiac injury; 3) function of Glucocorticoid Induced Leucine Zipper in the myocardium; 4) pharmacological agents that protect the heart from ischemic and chemotherapeutic injuries; and 5) biomarker discovery for predicting tissue injury due to oxidative stress.