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Bio
Dr. Li's research focuses on the generation of tumor-reactive T cells and B cells for the adoptive immunotherapy of cancer. To sensitize/induce tumor-reactive T cells and B cells in vivo, lymph node cells are primed utilizing as vaccines the genetically modified tumor cells, tumor cells admixed with bacterial adjutants, or antigen/antigen presenting cells. In order to optimize the methods that are capable of expanding lymphoid cells in vitro while maintaining or augmenting their antitumor reactivity, Dr. Li's research effort centers on developing new strategies for T and B cell activation/expansion using monoclonal antibodies and recombinant cytokines, as well as other T cell and/or B cell stimuli. Dr. Li's research effort is also devoted to the identification and characterization of tumor-specific T cell and B cell subsets. This issue is addressed by defining the specific antitumor reactivity of CD4+ cells or CD8+ cells, differentiating Th1/Tc1 versus Th2/Tc2 cytokine responses, studying molecules markers on T or B cells by T cell or B cell subsets. In addition, cancer stem cell model represents a new paradigm for the development of cancer immunotherapy. Conventional cytotoxic chemotherapy and immunologic approaches may kill most of the non-tumorigenic cells in a tumor, but cancer stem cells survive due to their relative high resistance to drugs or non-responsiveness to immunotherapy. Dr. Li's current research approaches involving development of novel therapeutic approaches by immunologically targeting cancer stem cells or by isolating and characterizing tumor associated antigens represent new directions taken in the laboratory.
Research Interests
Papers共 124 篇Author StatisticsCo-AuthorSimilar Experts
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Sook Ryun Park,Ming-Huang Chen,Arunee Dechaphunkul, Ningning Ding, Xiao Lin, Jinghui Zhang, Vivian Li,Qiao Li,Yi Ba
Cancer Researchno. 7 (2024)
Mingxia Jiang,Yue Chai,Jiaxuan Liu, Maiyue He,Yipeng Wang,Xue Yang,Zeyu Xing, Mengqi Zhang, Shihan Zhou,Fei Ma,Jiayu Wang,Peng Yuan,
BMC Cancerno. 1 (2024): 1-12
Nature communicationsno. 1 (2024): 5158-5158
Nilupai Abudureheiyimu,Yun Wu, Qing Li,Pin Zhang,Fei Ma,Peng Yuan,Yang Luo,Ying Fan,Shanshan Chen, Ruigang Cai,Qiao Li,Yiqun Han,
JOURNAL OF THE NATIONAL CANCER CENTERno. 2 (2023): 115-120
Signal Transduction and Targeted Therapyno. 1 (2023): 118-3
Cancer Researchno. 7_Supplement (2023): 2256-2256
Regular and Young Investigator Award Abstracts (2022): A1184-A1184
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