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Bio
Professor Pryor was a pioneer in the field of free radical research. His study of hydrogen atom transfer from thiols to radicals led to a publication that remains the simplest experimental demonstration of the Westheimer effect (which explains why the maximum kinetic isotope effect is observed in the most symmetrical atom transfer reaction), a paper designated a Citation Classic by the ISI. In the 1960's, he contrasted the displacement reaction on peroxides and disulfides by anions with those of radicals, and showed that radicals perform a “backside”, Walden inversion displacement reaction.
Dr. Pryor is an expert on oxidative stress and the use of the antioxidant vitamins in human health. Following the discovery of the enzyme superoxide dismutase in the 1960's, Dr. Pryor became the first free radical chemist to apply insights from organic free radical chemistry to the study of radical reactions in biology and medicine. He studied the oxidants and toxins in smog, including ozone, nitric oxide, nitrogen dioxide, peroxynitrites, peroxynitrates, and fine particulate matter.His research on ozone showed it is too reactive to penetrate far enough into cells to cause the effects that had been attributed to it. Instead, ozone reacts with the first reactive species that it contacts when it first enters the lung; those species are the unsaturated fatty acids present in the lung epithelial cell lining fluid (ELF). Ozone reacts with unsaturated lipids in the ELF to produce lipid ozonation products (LOP), and it is these LOP that act as biological signal transduction species and relay the inflammatory and ancillary effects of ozone into deeper tissue strata than ozone itself can reach.
Research Interests
Papers共 457 篇Author StatisticsCo-AuthorSimilar Experts
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CRC Press eBookspp.715-736, (2023)
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Revista de Químicano. 1 (2013)
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Revista de Químicano. 1 (2013)
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ChemInformno. 47 (2010)
mag(2010)
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