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Blood vessels are a prerequisite for the maintenance of all organ functions. Embryogenesis is dependent on the development and outgrowth of blood vessels, which provide the organism with oxygen and nutrients. Sprouting angiogenesis occurs rarely in the adult organism but can be observed for example during wound healing and also in cancer. Thus, a detailed knowledge about factors regulating angiogenesis and genetic networks, which provide a functional quiescent vascular bed, is highly desirable.
Besides the formation of new blood vessels, maintenance of existing blood vessels is essential as well. Endothelial cells provide the inner lining of all blood vessels. Disturbed endothelial cell functions are implicated in the pathogenesis of several cardiovascular diseases. Our research work aims at identifying critical molecular and cellular mechanisms of cardiovascular diseases and tumor progression. These findings will help to lay the foundation for the development of innovative pharmacological strategies
Our research group is towards this end
examining the signaling interplay between endothelial cells, as well as interactions of endothelial cells with pericytes and tumor cells.
investigate the role of Delta-Notch signaling and other genes, which are implicated in the formation of vascular malformations and vascular tumors.
studying novel factors necessary for barrier functions of blood vessels, and how these control the passage of tumor cells and fluids through the vessel wall. An important research approach deals with the question how genetic alterations in the endothelium affect metabolism.
Besides the formation of new blood vessels, maintenance of existing blood vessels is essential as well. Endothelial cells provide the inner lining of all blood vessels. Disturbed endothelial cell functions are implicated in the pathogenesis of several cardiovascular diseases. Our research work aims at identifying critical molecular and cellular mechanisms of cardiovascular diseases and tumor progression. These findings will help to lay the foundation for the development of innovative pharmacological strategies
Our research group is towards this end
examining the signaling interplay between endothelial cells, as well as interactions of endothelial cells with pericytes and tumor cells.
investigate the role of Delta-Notch signaling and other genes, which are implicated in the formation of vascular malformations and vascular tumors.
studying novel factors necessary for barrier functions of blood vessels, and how these control the passage of tumor cells and fluids through the vessel wall. An important research approach deals with the question how genetic alterations in the endothelium affect metabolism.
Research Interests
Papers共 130 篇Author StatisticsCo-AuthorSimilar Experts
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ALLERGY (2024)
Andreas Fischer, Elisenda Alsina-Sanchis
Yan Zhang, Michael Peel,Adrian Bot, Brittany Ross,Duy Nguyen,Michelle Nguyen, Theresa Hunter, Gregor Adams,Barzan A Sadiq,Haig Aghajanian, Ferran Soldevila,Daiki Matsuda,
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
Xinqiang Huang,Jill Magnus,Vivek Kaimal,Priya Karmali, Jian Li,Marlena Walls, Rene Prudente, Eric Sung, Mehran Sorourian,Robin Lee,Scott Davis,Xia Yang,
crossref(2023)
Nature cancerno. 11 (2023): 1544-+
CANCERSno. 20 (2023): 4924-4924
Suki Albers,Elizabeth C. Allen,Nikhil Bharti,Marcos Davyt,Disha Joshi,Carlos G. Perez-Garcia,Leonardo Santos,Rajesh Mukthavaram, Miguel Angel Delgado-Toscano, Brandon Molina,Kristen Kuakini,Maher Alayyoubi,
Natureno. 7966 (2023): 842-848
Elisenda Alsina-Sanchis,Ronja Mülfarth,Iris Moll,Sarah Böhn,Lena Wiedmann, Lorea Jordana-Urriza,Tara Ziegelbauer, Eleni Zimmer,Jacqueline Taylor,Francesca De Angelis Rigotti,Adrian Stögbauer,Benedetto Daniele Giaimo,
crossref(2023)
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Author Statistics
#Papers: 80
#Citation: 4118
H-Index: 29
G-Index: 64
Sociability: 6
Diversity: 3
Activity: 58
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