基本信息
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Career Trajectory
Bio
From the study of myeloid cells complexity to the regulation of their functions and development.
Antigen presenting cells (APC) include several subsets of macrophages and dendritic cells, which are specialized cells in acquiring, processing, and presenting antigens to T cells to induce for instance protective immune responses against tumors, such as tumor-specific CD8+ cytotoxic T-lymphocytes. These cells include different members, in steady-state and inflammatory conditions, which are heterogeneous in terms of cell-surface markers, function, and anatomical location. At the Immunological Center of Marseille-Luminy, Dr. Poulin contributed to the identification of mouse conventional type 1 dendritic cells (cDC1) within the skin dermis (Poulin et al., JEM 2007), and subsequently to their higher cross-presentation ability, a process aiming at presenting exogeneous antigens to CD8+ cytotoxic T-lymphocytes (Henri et al., JEM 2010). After this mouse discovery, Dr Poulin pioneered the DC characterization in human tissues and contributed to the identification of human cDC1 cells (Poulin et al., JEM 2010; Poulin et al., Blood 2012), these cells have been highlighted now as critical for immunotherapy success by stimulating anti-tumor immunity. At the Pasteur Institute of Lille, Dr. Poulin has contributed to the identification of CD64 as a monocyte-derived APC marker (Tamoutounour, EJI 2012), and has recently discovered and patented that type I IFN is a regulator of monocyte-derived APC by acting on monocyte precursors (Lasseaux et al., Sci Rep 2017).
Henri, S., L.F. Poulin, S. Tamoutounour, L. Ardouin, M. Guilliams, B. de Bovis, E. Devilard, C. Viret, H. Azukizawa, A. Kissenpfennig, and B. Malissen. 2010. CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med 207:189-206.
Lasseaux, C., M.P. Fourmaux, M. Chamaillard, and L.F. Poulin. 2017. Type I interferons drive inflammasome-independent emergency monocytopoiesis during endotoxemia. Scientific reports 7:16935.
Poulin, L.F., S. Henri, B. de Bovis, E. Devilard, A. Kissenpfennig, and B. Malissen. 2007. The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med 204:3119-3131.
Poulin, L.F., Y. Reyal, H. Uronen-Hansson, B.U. Schraml, D. Sancho, K.M. Murphy, U.K. Hakansson, L.F. Moita, W.W. Agace, D. Bonnet, and C. Reis e Sousa. 2012. DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues. Blood 119:6052-6062.
Poulin, L.F., M. Salio, E. Griessinger, F. Anjos-Afonso, L. Craciun, J.L. Chen, A.M. Keller, O. Joffre, S. Zelenay, E. Nye, A. Le Moine, F. Faure, V. Donckier, D. Sancho, V. Cerundolo, D. Bonnet, and C. Reis e Sousa. 2010. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med 207:1261-1271.
Tamoutounour, S., S. Henri, H. Lelouard, B. de Bovis, C. de Haar, C.J. van der Woude, A.M. Woltman, Y. Reyal, D. Bonnet, D. Sichien, C.C. Bain, A.M. Mowat, C. Reis e Sousa, L.F. Poulin, B. Malissen, and M. Guilliams. 2012. CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis. Eur J Immunol 42:3150-3166.
Research Support
2018 Research Grant from AFA (Association François-Aupetit) (PI), 20k€
2012-2017 AVENIR-ATIP program (PI), 540K€ (Decipher human dendritic cell subsets)
Research Interests
Papers共 39 篇Author StatisticsCo-AuthorSimilar Experts
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Thomas Paz Del Socorro,Kentaro Oka,Olivier Boulard,Motomichi Takahashi,Lionel Franz Poulin,Atsushi Hayashi,Mathias Chamaillard
GUT MICROBESno. 1 (2024)
Jared R. Coombs,Alina Zamoshnikova,Caroline L. Holley,Madhavi P. Maddugoda,Daniel Eng Thiam Teo,Camille Chauvin,Lionel F. Poulin,Nazarii Vitak,Connie M. Ross, Manasa Mellacheruvu,Rebecca C. Coll,Leonhard X. Heinz,
SCIENCE SIGNALINGno. 820 (2024): eabg8145-eabg8145
Thomas Paz Del Socorro,Kentaro Oka,Olivier Boulard,Motomichi Takahashi,Lionel Franz Poulin,Atsushi Hayashi,Mathias Chamaillard
Gut Microbesno. 1 (2024): 2315631-2315631
Gut microbesno. 2 (2023): 2249960
Camille Chauvin,Katarina Radulovic,Olivier Boulard,Myriam Delacre,Nadine Waldschmitt,Paul Régnier, Gauthier Legris, Clément Bouchez, Mohamed-Yassine Sleimi,Philip Rosenstiel,Guillaume Darrasse-Jèze,Mathias Chamaillard,
Frontiers in immunology (2023): 1252979-1252979
Frontiers in immunology (2023): 1181823
biorxiv(2022)
Camille Chauvin,Daniel Alvarez Simon,Paul Regnier,Katarina Radulovic,Olivier Boulard,Myriam Delacre,Nadine Waldschmitt, Laurent Peyrin Biroulet,Jerome Kluza, Guillaume Darrasse Jeze,Mathias Chamaillard,Lionel Franz Poulin
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