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个人简介
Dr. Pommier received an NIH Merit Award for his role in elucidating the function of topoisomerases as targets for anticancer drugs and NCI Director Award of Merit for "Pioneering work on the mechanism of topoisomerase and PARP inhibition and the discovery of novel biomarkers of the anticancer drug response". He has also received multiple Federal Technology Transfer Awards for discovering the mitochondrial topoisomerase TOP1MT and the importance of the ribonuclease activity of topoisomerases I, as wells as novel DNA topoisomerase, HIV-1 integrase and cell cycle checkpoint inhibitors. Three of his drugs are in clinical trial and his molecular pharmacology studies led to the clinical development of Yondelis and the PARP inhibitors. He serves as Senior Editor for Cancer Research for the Translational Science section and was elected Chair for 2004-2005 Gordon conferences on the Molecular Therapeutics of Cancer and for the 2016 and 2018 Gordon conferences on DNA Topoisomerases in Biology & Medicine. He is founding organizer of the "International Conferences on Retroviral Integrase: Molecular Biology and Pharmacology" (1995, 2001, 2008, 2014 and 2017). Dr. Pommier received the "Paul Ehrlich lecture award" from the French Society of Therapeutic Chemistry in 2005 based on his discovery of the Interfacial inhibition concept. He has authored over 700 publications and holds over 30 patents for inhibitors of DNA topoisomerases, tyrosyl-DNA phosphodiesterase, checkpoint inhibitors and HIV-1 integrase. He leads and developed the pharmacogenomic patient-derived cancer cell line CellMiner database for precision medicine. He discovered Schlafen 11 (SLFN11) as a dominant determinant of response to widely used anticancer agents. He has mentored over 60 M.D. and Ph.D. post-doctoral fellows, Howard Hughes Medical Institute trainees, Ph.D. graduate students, and students who went into medical and scientific academic positions, pharmaceutical and editorial careers. Dr. Pommier was elected fellow of the AAAS in 2017 and received the National Cancer Institute Director’s Award of Merit for “Pioneering work on the mechanism of topoisomerase and PARP inhibition and the discovery of novel biomarkers of the anticancer drug response”.
研究兴趣
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William C. Reinhold,Augustin Luna,Fathi Elloumi,Sudhir Varma,Daiki Taniyama,Makito Mizunuma,Jaydira del Rivero,Anish Thomas, Karyyne Reilly, Karel Pacak,Mirit Aladjem,Yves Pommier
Cancer Researchno. 6_Supplement (2024): 7175-7175
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iScienceno. 6 (2024): 109781-109781
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